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10.1038/sj.onc.1208236 http://scihub22266oqcxt.onion/10.1038/sj.onc.1208236 15592522!?!15592522 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=15592522&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Oncogene 2005 ; 24 (7): 1138-49 Nephropedia Template TP {{tp|p=15592522|t=2005. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase |pdf=|usr=}}{{15592522}} gab.com Text REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=15592522 #FOAvip Cancer cells frequently evade apoptosis during tumorigenesis by acquiring mutations in apoptotic regulators. Chronic activation of the PI 3-kinase-Akt pathway through loss of the tumor suppressor PTEN is one mechanism by which these cells can gain increased protection against apoptosis. We report here that REDD1 (RTP801) can act as a transcriptional downstream target of PI 3-kinase signaling in human prostate cancer cells (PC-3). REDD1 expression is markedly reduced in PC-3 cells treated with LY294002 (LY) or Rapamycin and strongly induced under hypoxic conditions in a hypoxia-inducible factor-1 (HIF-1)-dependent manner. Loss of function studies employing antisense molecules or RNA interference indicate that REDD1 is essential for invasive growth of prostate cancer cells in vitro and in vivo. Reduced REDD1 levels can sensitize cells towards apoptosis, whereas elevated levels of REDD1 induced by hypoxia or overexpression desensitize cells to apoptotic stimuli. Taken together our data designate REDD1 as a novel target for therapeutic intervention in prostate cancer. Twit Text FOAVip REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=15592522 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15592522 #FOAvip English Wikipedia <ref>{{Cite pmid|15592522}}</ref> REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase #MMPMID15592522 Schwarzer R; Tondera D; Arnold W; Giese K; Klippel A; Kaufmann J Oncogene 2005[Feb]; 24 (7): 1138-49 PMID15592522show ga Cancer cells frequently evade apoptosis during tumorigenesis by acquiring mutations in apoptotic regulators. Chronic activation of the PI 3-kinase-Akt pathway through loss of the tumor suppressor PTEN is one mechanism by which these cells can gain increased protection against apoptosis. We report here that REDD1 (RTP801) can act as a transcriptional downstream target of PI 3-kinase signaling in human prostate cancer cells (PC-3). REDD1 expression is markedly reduced in PC-3 cells treated with LY294002 (LY) or Rapamycin and strongly induced under hypoxic conditions in a hypoxia-inducible factor-1 (HIF-1)-dependent manner. Loss of function studies employing antisense molecules or RNA interference indicate that REDD1 is essential for invasive growth of prostate cancer cells in vitro and in vivo. Reduced REDD1 levels can sensitize cells towards apoptosis, whereas elevated levels of REDD1 induced by hypoxia or overexpression desensitize cells to apoptotic stimuli. Taken together our data designate REDD1 as a novel target for therapeutic intervention in prostate cancer. |Apoptosis[MESH] |Cell Hypoxia[MESH] |Cell Line, Tumor[MESH] |Chromones/pharmacology[MESH] |Cobalt/pharmacology[MESH] |Dimethyl Sulfoxide/pharmacology[MESH] |Gene Expression/genetics[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit[MESH] |Male[MESH] |Morpholines/pharmacology[MESH] |Neoplasm Invasiveness/genetics[MESH] |Phosphatidylinositol 3-Kinases/genetics/*physiology[MESH] |Phosphoinositide-3 Kinase Inhibitors[MESH] |Prostatic Neoplasms/genetics/immunology/*metabolism[MESH] |RNA, Antisense/genetics[MESH] |Signal Transduction[MESH] |Sirolimus/pharmacology[MESH] |Transcription Factors/analysis/genetics/*physiology[MESH]REDD1 integrates hypoxia-mediated survival signaling downstream of ph(epmc).pdf DeepDyve Pubget Overpricing