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pmid15577097      Clin+Calcium 2004 ; 14 (8): 50-7
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  • Physiological role of Mg2+ in neurons #MMPMID15577097
  • Sato Y; Fukuda J
  • Clin Calcium 2004[Aug]; 14 (8): 50-7 PMID15577097show ga
  • Physiological role of Mg ions in living cells is now in the process of reexamination. This is triggered by the finding that cytoplasmic Mg(2+) concentration measured by a fluorescent dye, mag fura-2, is surprisingly small, being not more than 1 mM. Lines of examination have revealed that Mg(2+) inhibits various species of ionc channels not only from outside but also from inside of the plasma membrane. Entry of Mg(2+) into intracellular space is revealed to take place via a Ca(2+)-channels, TRPM7; this channel may thus be called "Mg(2+)-channel". Moreover, an excess amount of intracellular Mg(2+) induced by hyper-activity of NMDA channels occasionally causes neuronal cell death as a result of inhibitory effects of Mg(2+) to mitochondrial activities.
  • |Calcium/physiology[MESH]
  • |Cations, Divalent[MESH]
  • |Cell Death[MESH]
  • |Glutamic Acid/toxicity[MESH]
  • |Homeostasis[MESH]
  • |Ion Channels/physiology[MESH]
  • |Magnesium/*physiology[MESH]
  • |Membrane Proteins/physiology[MESH]
  • |Mitochondria/physiology[MESH]
  • |Neurons[MESH]
  • |Protein Kinases/physiology[MESH]
  • |Protein Serine-Threonine Kinases[MESH]
  • |Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/physiology[MESH]


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