Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=15577097&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538
Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Clin+Calcium 2004 ; 14 (8): 50-7 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Physiological role of Mg2+ in neurons #MMPMID15577097
Sato Y; Fukuda J
Clin Calcium 2004[Aug]; 14 (8): 50-7 PMID15577097show ga
Physiological role of Mg ions in living cells is now in the process of reexamination. This is triggered by the finding that cytoplasmic Mg(2+) concentration measured by a fluorescent dye, mag fura-2, is surprisingly small, being not more than 1 mM. Lines of examination have revealed that Mg(2+) inhibits various species of ionc channels not only from outside but also from inside of the plasma membrane. Entry of Mg(2+) into intracellular space is revealed to take place via a Ca(2+)-channels, TRPM7; this channel may thus be called "Mg(2+)-channel". Moreover, an excess amount of intracellular Mg(2+) induced by hyper-activity of NMDA channels occasionally causes neuronal cell death as a result of inhibitory effects of Mg(2+) to mitochondrial activities.