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10.1016/j.tim.2004.08.008 http://scihub22266oqcxt.onion/10.1016/j.tim.2004.08.008 15381196!7119031!15381196     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\15381196.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Microbiol 2004 ; 12 (10): 466-72 Nephropedia Template TP {{tp|p=15381196|t=2004. Cellular entry of the SARS coronavirus |pdf=|usr=}}{{15381196}} gab.com Text Cellular entry of the SARS coronavirus JO: Trends Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=15381196 #FOAvip Enveloped viruses have evolved membrane glycoproteins (GPs) that mediate entry into host cells. These proteins are important targets for antiviral therapies and vaccines. Several efforts to understand and combat infection by severe acute respiratory syndrome coronavirus (SARS-CoV) have therefore focused on the viral GP, known as spike (S). In a short period of time, important aspects of SARS-CoV S-protein function were unraveled. The identification of angiotensin-converting enzyme 2 (ACE2) as a receptor for SARS-CoV provided an insight into viral tropism and pathogenesis, whereas mapping of functional domains in the S-protein enabled inhibitors to be generated. Vaccines designed on the basis of SARS-CoV S-protein were shown to be effective in animals and consequently are attractive candidates for vaccine trials in humans. Here, we discuss how SARS-CoV S facilitates viral entry into target cells and illustrate current approaches that are used to inhibit this process. Twit Text FOAVip Cellular entry of the SARS coronavirus ????Trends Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=15381196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15381196 #FOAvip English Wikipedia <ref>{{Cite pmid|15381196}}</ref> Cellular entry of the SARS coronavirus #MMPMID15381196 Hofmann H; Pohlmann S Trends Microbiol 2004[Oct]; 12 (10): 466-72 PMID15381196show ga Enveloped viruses have evolved membrane glycoproteins (GPs) that mediate entry into host cells. These proteins are important targets for antiviral therapies and vaccines. Several efforts to understand and combat infection by severe acute respiratory syndrome coronavirus (SARS-CoV) have therefore focused on the viral GP, known as spike (S). In a short period of time, important aspects of SARS-CoV S-protein function were unraveled. The identification of angiotensin-converting enzyme 2 (ACE2) as a receptor for SARS-CoV provided an insight into viral tropism and pathogenesis, whereas mapping of functional domains in the S-protein enabled inhibitors to be generated. Vaccines designed on the basis of SARS-CoV S-protein were shown to be effective in animals and consequently are attractive candidates for vaccine trials in humans. Here, we discuss how SARS-CoV S facilitates viral entry into target cells and illustrate current approaches that are used to inhibit this process. |Animals[MESH] |Dendritic Cells/immunology/metabolism/virology[MESH] |Humans[MESH] |Membrane Glycoproteins/*metabolism[MESH] |Peptidyl-Dipeptidase A/*metabolism[MESH] |Receptors, Virus/metabolism[MESH] |Severe Acute Respiratory Syndrome/immunology/*virology[MESH] |Severe acute respiratory syndrome-related coronavirus/*metabolism/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus[MESH] |Viral Envelope Proteins/*metabolism[MESH]Cellular entry of the SARS coronavirus (epmc).pdf DeepDyve Pubget Overpricing