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10.1111/j.1523-1755.2004.00873.x http://scihub22266oqcxt.onion/10.1111/j.1523-1755.2004.00873.x 15327418!ä!15327418 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2004 ; 66 (3): 1199-205 Nephropedia Template TP {{tp|p=15327418|t=2004. Idiopathic membranous nephropathy: definition and relevance of a partial remission |pdf=|usr=}}{{15327418}} gab.com Text Idiopathic membranous nephropathy: definition and relevance of a partial remission JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=15327418 #FOAvip BACKGROUND: Membranous nephropathy (MGN) remains the most common cause of adult onset nephrotic syndrome, and within the primary glomerulonephritis group is a leading cause of renal failure. A complete remission (CR) confers an excellent long-term prognosis, but the quantitative benefits of partial remissions (PR) have not been defined. METHODS: This study evaluated the rate of renal function decline (slope), relapse, and renal survival in nephrotic MGN patients with CR, PR, or no remission (NR). Multivariate analysis included clinical and laboratory data at presentation and over follow-up, blood pressure control and agents employed, and immunosuppressive therapy. RESULTS: The study cohort consisted of 348 nephrotic MGN patients with a minimum of 12 months follow-up identified from the Toronto Glomerulonephritis Registry. Over a median follow-up of 60 months, 102 experienced a CR, 136 had a PR, and 110 had no remission. A PR was independently predictive of slope and survival from renal failure by multivariate analysis (hazard ratio 0.08, 95% CI 0.03-0.19, P < 0.001). Benefit from immunosuppression could only be shown in a subset of high-risk patients. Treatment-related PR had the same long-term implication as spontaneous ones. Relapses from PR were high (47%) but often reversible. CONCLUSION: A partial remission is an important therapeutic target with implications for both progression rate and renal survival. Twit Text FOAVip Idiopathic membranous nephropathy: definition and relevance of a partial remission ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=15327418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15327418 #FOAvip English Wikipedia <ref>{{Cite pmid|15327418}}</ref> Idiopathic membranous nephropathy: definition and relevance of a partial remission #MMPMID15327418 Troyanov S; Wall CA; Miller JA; Scholey JW; Cattran DC Kidney Int 2004[Sep]; 66 (3): 1199-205 PMID15327418show ga BACKGROUND: Membranous nephropathy (MGN) remains the most common cause of adult onset nephrotic syndrome, and within the primary glomerulonephritis group is a leading cause of renal failure. A complete remission (CR) confers an excellent long-term prognosis, but the quantitative benefits of partial remissions (PR) have not been defined. METHODS: This study evaluated the rate of renal function decline (slope), relapse, and renal survival in nephrotic MGN patients with CR, PR, or no remission (NR). Multivariate analysis included clinical and laboratory data at presentation and over follow-up, blood pressure control and agents employed, and immunosuppressive therapy. RESULTS: The study cohort consisted of 348 nephrotic MGN patients with a minimum of 12 months follow-up identified from the Toronto Glomerulonephritis Registry. Over a median follow-up of 60 months, 102 experienced a CR, 136 had a PR, and 110 had no remission. A PR was independently predictive of slope and survival from renal failure by multivariate analysis (hazard ratio 0.08, 95% CI 0.03-0.19, P < 0.001). Benefit from immunosuppression could only be shown in a subset of high-risk patients. Treatment-related PR had the same long-term implication as spontaneous ones. Relapses from PR were high (47%) but often reversible. CONCLUSION: A partial remission is an important therapeutic target with implications for both progression rate and renal survival. |Adult[MESH] |Cohort Studies[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Glomerulonephritis, Membranous/drug therapy/*mortality/physiopathology[MESH] |Humans[MESH] |Immunosuppressive Agents/therapeutic use[MESH] |Male[MESH] |Middle Aged[MESH] |Proteinuria/drug therapy/mortality/physiopathology[MESH] |Recurrence[MESH] |Registries[MESH] |Remission Induction[MESH]Idiopathic membranous nephropathy: definition and relevance of a parti(epmc).pdf DeepDyve Pubget Overpricing