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10.1007/s0054010050213

http://scihub22266oqcxt.onion/10.1007/s0054010050213
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15278621!ä!15278621

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suck abstract from ncbi


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pmid15278621      J+Anesth 1991 ; 5 (3): 213-20
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  • Effects of lidocaine and verapamil on early afterdepolarizations in isolated rabbit sinoatrial node #MMPMID15278621
  • Miyamae S; Matsuda T; Goto K; Mori H
  • J Anesth 1991[Jul]; 5 (3): 213-20 PMID15278621show ga
  • The effects of local anaesthetic anti-arrhythmic agents (lidocaine) and Ca antagonists (Verapamil) have been examined on the early afterdepolarizations (EADs) in isolated rabbit sinoatrial (SA) node. In a nominally calcium free and magnesium free solution, strontium (0.5-4.5 mM) produced an EAD in small pieces isolated from the SA node. The additional presence of 0.02-0.6 mM lidocaine did not abolish the strontium (0.5 mM)-induced EAD. 0.6 mM lidocaine produced an increase in EAD amplitude and then abolished a prolonged action potential (AP) associated with repetitive EADs. On the other hand, the addition of 4 micro M verapamil abolished the strontium (0.5 mM)-induced EAD but did not abolish the AP.It is concluded that under conditions when the AP is not abolished, EAD blockade by lidocaine is less effective than that by verapamil.
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