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10.1099/vir.0.80105-0 http://scihub22266oqcxt.onion/10.1099/vir.0.80105-0 15269377!ä!15269377 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Virol 2004 ; 85 (Pt 8): 2357-2364 Nephropedia Template TP {{tp|p=15269377|t=2004. Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages |pdf=|usr=}}{{15269377}} gab.com Text Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=15269377 #FOAvip NK cells participate in innate immune responses by secreting gamma interferon (IFN-gamma) and by destroying virus-infected cells. Here the interaction between influenza A or Sendai virus-infected macrophages and NK cells has been studied. A rapid, cell-cell contact-dependent production of IFN-gamma from NK cells cultured with virus-infected macrophages was observed. Expression of the MHC class I-related chain B (MICB) gene, a ligand for NK cell-activating receptor NKG2D, was upregulated in virus-infected macrophages suggesting a role for MICB in the activation of the IFN-gamma gene in NK cells. IL12Rbeta2, IL18R and T-bet mRNA synthesis was enhanced in NK cells cultured with virus-infected macrophages. Upregulation of these genes was dependent on macrophage-derived IFN-alpha. In contrast to IL12Rbeta2, expression of WSX-1/TCCR, a receptor for IL27, was reduced in NK cells in response to virus-induced IFN-alpha. In conclusion, these results show that virus-infected macrophages activate NK cells via cytokines and direct cellular interactions and further emphasize the role of IFN-alpha in the activation of innate immunity. Twit Text FOAVip Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=15269377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15269377 #FOAvip English Wikipedia <ref>{{Cite pmid|15269377}}</ref> Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages #MMPMID15269377 Siren J; Sareneva T; Pirhonen J; Strengell M; Veckman V; Julkunen I; Matikainen S J Gen Virol 2004[Aug]; 85 (Pt 8): 2357-2364 PMID15269377show ga NK cells participate in innate immune responses by secreting gamma interferon (IFN-gamma) and by destroying virus-infected cells. Here the interaction between influenza A or Sendai virus-infected macrophages and NK cells has been studied. A rapid, cell-cell contact-dependent production of IFN-gamma from NK cells cultured with virus-infected macrophages was observed. Expression of the MHC class I-related chain B (MICB) gene, a ligand for NK cell-activating receptor NKG2D, was upregulated in virus-infected macrophages suggesting a role for MICB in the activation of the IFN-gamma gene in NK cells. IL12Rbeta2, IL18R and T-bet mRNA synthesis was enhanced in NK cells cultured with virus-infected macrophages. Upregulation of these genes was dependent on macrophage-derived IFN-alpha. In contrast to IL12Rbeta2, expression of WSX-1/TCCR, a receptor for IL27, was reduced in NK cells in response to virus-induced IFN-alpha. In conclusion, these results show that virus-infected macrophages activate NK cells via cytokines and direct cellular interactions and further emphasize the role of IFN-alpha in the activation of innate immunity. |*Cell Communication[MESH] |*Lymphocyte Activation[MESH] |Coculture Techniques[MESH] |Cytokines/*physiology[MESH] |Gene Expression Regulation[MESH] |Histocompatibility Antigens Class I[MESH] |Humans[MESH] |Influenza A virus/*physiology[MESH] |Interferon-alpha/physiology[MESH] |Interferon-gamma/biosynthesis[MESH] |Killer Cells, Natural/*immunology[MESH] |Macrophages/*physiology/virology[MESH] |Proteins/genetics[MESH]Cytokine and contact-dependent activation of natural killer cells by i(epmc).pdf DeepDyve Pubget Overpricing