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10.1111/j.1474-9728.2004.00102.x

http://scihub22266oqcxt.onion/10.1111/j.1474-9728.2004.00102.x
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15268749!ä!15268749

suck abstract from ncbi


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pmid15268749      Aging+Cell 2004 ; 3 (4): 161-7
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  • Innate immunity in aging: impact on macrophage function #MMPMID15268749
  • Plowden J; Renshaw-Hoelscher M; Engleman C; Katz J; Sambhara S
  • Aging Cell 2004[Aug]; 3 (4): 161-7 PMID15268749show ga
  • Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as 'pathogen sensors' and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.
  • |Aging/*immunology/physiology[MESH]
  • |Animals[MESH]
  • |Antimicrobial Cationic Peptides/immunology/physiology[MESH]
  • |Cell Lineage/physiology[MESH]
  • |Chemokines/metabolism[MESH]
  • |Cytokines/metabolism[MESH]
  • |Humans[MESH]
  • |Immunity, Innate/*physiology[MESH]
  • |Langerhans Cells/immunology/physiology[MESH]
  • |Macrophages/immunology/metabolism/*physiology[MESH]
  • |Membrane Glycoproteins/physiology[MESH]
  • |Phagocytosis/immunology/physiology[MESH]
  • |Receptors, Cell Surface/physiology[MESH]
  • |Toll-Like Receptors[MESH]


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