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10.1099/vir.0.80002-0

http://scihub22266oqcxt.onion/10.1099/vir.0.80002-0
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15218174!ä!15218174

suck abstract from ncbi


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pmid15218174      J+Gen+Virol 2004 ; 85 (Pt 7): 1895-1898
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  • The X protein of Borna disease virus regulates viral polymerase activity through interaction with the P protein #MMPMID15218174
  • Poenisch M; Unterstab G; Wolff T; Staeheli P; Schneider U
  • J Gen Virol 2004[Jul]; 85 (Pt 7): 1895-1898 PMID15218174show ga
  • Borna disease virus polymerase activity is negatively regulated by the viral X protein. Using a virus minireplicon system it was found that all X mutants that no longer interacted with the viral P protein failed to exhibit significant inhibitory activity. The action of X could further be neutralized by expression of a P fragment that contained the X interaction domain but lacked all domains known to mediate interaction with other viral proteins. X thus appears to regulate the activity of the Borna disease virus polymerase by targeting the polymerase cofactor P.
  • |Borna disease virus/*metabolism[MESH]
  • |DNA-Directed RNA Polymerases/*metabolism[MESH]
  • |Genome, Viral[MESH]
  • |RNA, Viral/genetics[MESH]


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