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10.2169/internalmedicine.43.410

http://scihub22266oqcxt.onion/10.2169/internalmedicine.43.410
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15206555!ä!15206555

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suck abstract from ncbi


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pmid15206555      Intern+Med 2004 ; 43 (5): 410-4
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  • Depressive state and paresthesia dramatically improved by intravenous MgSO4 in Gitelman s syndrome #MMPMID15206555
  • Enya M; Kanoh Y; Mune T; Ishizawa M; Sarui H; Yamamoto M; Takeda N; Yasuda K; Yasujima M; Tsutaya S; Takeda J
  • Intern Med 2004[May]; 43 (5): 410-4 PMID15206555show ga
  • A 69-year-old woman was referred to our department for evaluation of hypokalemia, which had been treated by oral potassium for more than ten years. She complained of headache, knee joint pain, sleeplessness and paresthesia in extremities and, most prominently, depression. Laboratory data suggested Gitelman's syndrome, which is caused by mutations in the gene encoding the thiazide-sensitive Na-Cl cotransporter. Direct sequencing of the gene in this patient revealed homozygous mutation R964Q in exon 25. Intravenous supplement of MgSO4 dramatically improved both the depression and the paresthesia, suggesting that hypomagnesemia played a role in the clinical manifestations.
  • |Aged[MESH]
  • |Alkalosis/diagnosis[MESH]
  • |Bartter Syndrome/*diagnosis[MESH]
  • |Depressive Disorder/diagnosis/*drug therapy[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Hyperaldosteronism/diagnosis[MESH]
  • |Hypocalcemia/diagnosis[MESH]
  • |Hypokalemia/diagnosis[MESH]
  • |Infusions, Intravenous[MESH]
  • |Magnesium Deficiency/diagnosis/*prevention & control[MESH]
  • |Magnesium Sulfate/*administration & dosage[MESH]
  • |Paresthesia/diagnosis/*drug therapy[MESH]
  • |Risk Assessment[MESH]
  • |Syndrome[MESH]


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