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10.1016/j.peptides.2003.10.008 http://scihub22266oqcxt.onion/10.1016/j.peptides.2003.10.008 15127935!7124255!15127935     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Peptides 2003 ; 24 (12): 1837-45 Nephropedia Template TP {{tp|p=15127935|t=2003. Prediction of amino acid pairs sensitive to mutations in the spike protein from SARS related coronavirus |pdf=|usr=}}{{15127935}} gab.com Text Prediction of amino acid pairs sensitive to mutations in the spike protein from SARS related coronavirus JO: Peptides http://www.kidney.de/pget.php?&tw=1&pmid=15127935 #FOAvip In this study, we analyzed the amino acid pairs affected by mutations in two spike proteins from human coronavirus strains 229E and OC43 by means of random analysis in order to gain some insight into the possible mutations in the spike protein from SARS-CoV. The results demonstrate that the randomly unpredictable amino acid pairs are more sensitive to the mutations. The larger is the difference between actual and predicted frequencies, the higher is the chance of mutation occurring. The effect induced by mutations is to reduce the difference between actual and predicted frequencies. The amino acid pairs whose actual frequencies are larger than their predicted frequencies are more likely to be targeted by mutations, whereas the amino acid pairs whose actual frequencies are smaller than their predicted frequencies are more likely to be formed after mutations. These findings are identical to our several recent studies, i.e. the mutations represent a process of degeneration inducing human diseases. Twit Text FOAVip Prediction of amino acid pairs sensitive to mutations in the spike protein from SARS related coronavirus ????Peptides http://www.kidney.de/pget.php?&tw=1&pmid=15127935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15127935 #FOAvip English Wikipedia <ref>{{Cite pmid|15127935}}</ref> Prediction of amino acid pairs sensitive to mutations in the spike protein from SARS related coronavirus #MMPMID15127935 Wu G; Yan S Peptides 2003[Dec]; 24 (12): 1837-45 PMID15127935show ga In this study, we analyzed the amino acid pairs affected by mutations in two spike proteins from human coronavirus strains 229E and OC43 by means of random analysis in order to gain some insight into the possible mutations in the spike protein from SARS-CoV. The results demonstrate that the randomly unpredictable amino acid pairs are more sensitive to the mutations. The larger is the difference between actual and predicted frequencies, the higher is the chance of mutation occurring. The effect induced by mutations is to reduce the difference between actual and predicted frequencies. The amino acid pairs whose actual frequencies are larger than their predicted frequencies are more likely to be targeted by mutations, whereas the amino acid pairs whose actual frequencies are smaller than their predicted frequencies are more likely to be formed after mutations. These findings are identical to our several recent studies, i.e. the mutations represent a process of degeneration inducing human diseases. |*Mutation[MESH] |Amino Acids/*metabolism[MESH] |Computational Biology[MESH] |Coronavirus 229E, Human/chemistry[MESH] |Coronavirus OC43, Human/chemistry[MESH] |Coronavirus/*chemistry[MESH] |Humans[MESH] |Membrane Glycoproteins/*chemistry/*genetics[MESH] |Severe acute respiratory syndrome-related coronavirus/*chemistry[MESH] |Spike Glycoprotein, Coronavirus[MESH]Prediction of amino acid pairs sensitive to mutations in the spike pro(epmc).pdf DeepDyve Pubget Overpricing