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10.1128/AAC.48.4.1422-1425.2004 http://scihub22266oqcxt.onion/10.1128/AAC.48.4.1422-1425.2004 15047559/?report=reader!375289!15047559     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antimicrob+Agents+Chemother 2004 ; 48 (4): 1422-5 Nephropedia Template TP {{tp|p=15047559|t=2004. 2 -fluoro-2 -deoxycytidine inhibits Borna disease virus replication and spread |pdf=|usr=}}{{15047559}} gab.com Text 2 -fluoro-2 -deoxycytidine inhibits Borna disease virus replication and spread JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=15047559 #FOAvip Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV. Twit Text FOAVip 2 -fluoro-2 -deoxycytidine inhibits Borna disease virus replication and spread ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=15047559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15047559 #FOAvip English Wikipedia <ref>{{Cite pmid|15047559}}</ref> 2 -fluoro-2 -deoxycytidine inhibits Borna disease virus replication and spread #MMPMID15047559 Bajramovic JJ; Volmer R; Syan S; Pochet S; Gonzalez-Dunia D Antimicrob Agents Chemother 2004[Apr]; 48 (4): 1422-5 PMID15047559show ga Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Borna Disease/virology[MESH] |Borna disease virus/*drug effects[MESH] |Chlorocebus aethiops[MESH] |Cytarabine/pharmacology[MESH] |Deoxycytidine/*analogs & derivatives/*pharmacology[MESH] |RNA, Viral/biosynthesis/genetics[MESH] |Vero Cells[MESH]2 -fluoro-2 -deoxycytidine inhibits Borna disease virus replication an(epmc).pdf DeepDyve Pubget Overpricing