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10.1096/fj.03-0764fje http://scihub22266oqcxt.onion/10.1096/fj.03-0764fje 15033926!ä!15033926 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FASEB+J 2004 ; 18 (7): 863-5 Nephropedia Template TP {{tp|p=15033926|t=2004. Persistent, noncytolytic infection of neurons by Borna disease virus interferes with ERK 1/2 signaling and abrogates BDNF-induced synaptogenesis |pdf=|usr=}}{{15033926}} gab.com Text Persistent, noncytolytic infection of neurons by Borna disease virus interferes with ERK 1/2 signaling and abrogates BDNF-induced synaptogenesis JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=15033926 #FOAvip Infection of the central nervous system by Borna disease virus (BDV) provides a unique model to study the mechanisms whereby a persistent viral infection can impair neuronal function and cause behavioral diseases reminiscent of mood disorders, schizophrenia, or autism in humans. In the present work, we studied the effect of BDV infection on the response of hippocampal neurons, the main target for this virus, to the neurotrophin BDNF. We showed that persistent infection did not affect neuronal survival or morphology. However, it blocked BDNF-induced ERK 1/2 phosphorylation, despite normal expression of the TrkB BDNF receptor. In addition, BDNF-induced expression of synaptic vesicle proteins was abrogated, which resulted in severely impaired synaptogenesis and defects in synaptic organization. Thus, we provide the first evidence that a virus can interfere specifically with neurotrophin-regulated neuroplasticity, thereby hampering proper neuronal connectivity. These results may help to understand the behavioral disorders associated with BDV infection. Twit Text FOAVip Persistent, noncytolytic infection of neurons by Borna disease virus interferes with ERK 1/2 signaling and abrogates BDNF-induced synaptogenesis ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=15033926 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15033926 #FOAvip English Wikipedia <ref>{{Cite pmid|15033926}}</ref> Persistent, noncytolytic infection of neurons by Borna disease virus interferes with ERK 1/2 signaling and abrogates BDNF-induced synaptogenesis #MMPMID15033926 Hans A; Bajramovic JJ; Syan S; Perret E; Dunia I; Brahic M; Gonzalez-Dunia D FASEB J 2004[May]; 18 (7): 863-5 PMID15033926show ga Infection of the central nervous system by Borna disease virus (BDV) provides a unique model to study the mechanisms whereby a persistent viral infection can impair neuronal function and cause behavioral diseases reminiscent of mood disorders, schizophrenia, or autism in humans. In the present work, we studied the effect of BDV infection on the response of hippocampal neurons, the main target for this virus, to the neurotrophin BDNF. We showed that persistent infection did not affect neuronal survival or morphology. However, it blocked BDNF-induced ERK 1/2 phosphorylation, despite normal expression of the TrkB BDNF receptor. In addition, BDNF-induced expression of synaptic vesicle proteins was abrogated, which resulted in severely impaired synaptogenesis and defects in synaptic organization. Thus, we provide the first evidence that a virus can interfere specifically with neurotrophin-regulated neuroplasticity, thereby hampering proper neuronal connectivity. These results may help to understand the behavioral disorders associated with BDV infection. |*MAP Kinase Signaling System/drug effects[MESH] |Animals[MESH] |Borna disease virus/*physiology[MESH] |Brain-Derived Neurotrophic Factor/*antagonists & inhibitors/physiology[MESH] |Cells, Cultured/drug effects/enzymology/ultrastructure/virology[MESH] |Cytopathogenic Effect, Viral[MESH] |Hippocampus/cytology/virology[MESH] |Mental Disorders/virology[MESH] |Mitogen-Activated Protein Kinase 1/*physiology[MESH] |Mitogen-Activated Protein Kinase 3[MESH] |Mitogen-Activated Protein Kinases/*physiology[MESH] |Nerve Tissue Proteins/biosynthesis[MESH] |Neuronal Plasticity[MESH] |Neurons/drug effects/enzymology/ultrastructure/*virology[MESH] |Phosphorylation[MESH] |Protein Processing, Post-Translational[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Receptor, trkB/metabolism[MESH]Persistent, noncytolytic infection of neurons by Borna disease virus i(epmc).pdf DeepDyve Pubget Overpricing