Development 2004 ; 131 (7): 1449-62 Nephropedia Template TP
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Branching morphogenesis and kidney disease #MMPMID15023929
Shah MM; Sampogna RV; Sakurai H; Bush KT; Nigam SK
Development 2004[Apr]; 131 (7): 1449-62 PMID15023929show ga
Branching morphogenesis in the kidney is a tightly regulated, complex process and its disruption potentially can lead to a broad spectrum of diseases, ranging from rare hereditary syndromes to common conditions such as hypertension and chronic kidney failure. This review synthesizes data on branching during kidney development derived from in vitro and in vivo rodent studies and to apply them to human diseases. It discusses how the broad organization of molecular interactions during kidney development might provide a mechanistic framework for understanding disorders related to aberrant branching.