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10.1016/j.clpt.2003.11.376 http://scihub22266oqcxt.onion/10.1016/j.clpt.2003.11.376 15001976!ä!15001976 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Pharmacol+Ther 2004 ; 75 (3): 242-7 Nephropedia Template TP {{tp|p=15001976|t=2004. Torsades de pointes associated with fluoroquinolones: importance of concomitant risk factors |pdf=|usr=}}{{15001976}} gab.com Text Torsades de pointes associated with fluoroquinolones: importance of concomitant risk factors JO: Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=15001976 #FOAvip The fluoroquinolone antibiotics sparfloxacin, grepafloxacin, gatifloxacin, and levofloxacin have been reported to cause torsades de pointes. Pre-existing risk factors increase vulnerability to this life-threatening arrhythmia. In a 65-year-old woman with a history of hypertension, coronary artery disease, systemic lupus erythematosus, and osteomyelitis, QTc interval prolongation (605 ms) and torsades de pointes developed after the initiation of levofloxacin, 250 mg intravenously once daily. The patient was hypokalemic and mildly hypomagnesemic before the initiation of levofloxacin and at the time of occurrence of torsades de pointes. The QTc interval decreased to 399 ms within hours of discontinuation of the levofloxacin, after which she had no further arrhythmias. In this and the majority of other published cases of fluoroquinolone-associated torsades de pointes, patients had at least 1 risk factor for the arrhythmia, and most had multiple risk factors. Fluoroquinolone antibiotics should be avoided whenever possible in patients with pre-existing risk factors for torsades de pointes. Twit Text FOAVip Torsades de pointes associated with fluoroquinolones: importance of concomitant risk factors ????Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=15001976 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15001976 #FOAvip English Wikipedia <ref>{{Cite pmid|15001976}}</ref> Torsades de pointes associated with fluoroquinolones: importance of concomitant risk factors #MMPMID15001976 Amankwa K; Krishnan SC; Tisdale JE Clin Pharmacol Ther 2004[Mar]; 75 (3): 242-7 PMID15001976show ga The fluoroquinolone antibiotics sparfloxacin, grepafloxacin, gatifloxacin, and levofloxacin have been reported to cause torsades de pointes. Pre-existing risk factors increase vulnerability to this life-threatening arrhythmia. In a 65-year-old woman with a history of hypertension, coronary artery disease, systemic lupus erythematosus, and osteomyelitis, QTc interval prolongation (605 ms) and torsades de pointes developed after the initiation of levofloxacin, 250 mg intravenously once daily. The patient was hypokalemic and mildly hypomagnesemic before the initiation of levofloxacin and at the time of occurrence of torsades de pointes. The QTc interval decreased to 399 ms within hours of discontinuation of the levofloxacin, after which she had no further arrhythmias. In this and the majority of other published cases of fluoroquinolone-associated torsades de pointes, patients had at least 1 risk factor for the arrhythmia, and most had multiple risk factors. Fluoroquinolone antibiotics should be avoided whenever possible in patients with pre-existing risk factors for torsades de pointes. |*Levofloxacin[MESH] |Aged[MESH] |Cardiovascular Diseases/drug therapy/physiopathology[MESH] |Female[MESH] |Fluoroquinolones/*adverse effects[MESH] |Humans[MESH] |Lupus Erythematosus, Systemic/drug therapy/physiopathology[MESH] |Ofloxacin/*adverse effects[MESH] |Osteomyelitis/drug therapy/physiopathology[MESH] |Risk Factors[MESH]Torsades de pointes associated with fluoroquinolones: importance of co(epmc).pdf DeepDyve Pubget Overpricing