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10.1086/382897 http://scihub22266oqcxt.onion/10.1086/382897 14991528/?report=reader!1181938!14991528     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=14991528&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Hum+Genet 2004 ; 74 (4): 599-609 Nephropedia Template TP {{tp|p=14991528|t=2004. Epigenetics and assisted reproductive technology: a call for investigation |pdf=|usr=}}{{14991528}} gab.com Text Epigenetics and assisted reproductive technology: a call for investigation JO: Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=14991528 #FOAvip A surprising set of recent observations suggests a link between assisted reproductive technology (ART) and epigenetic errors--that is, errors involving information other than DNA sequence that is heritable during cell division. An apparent association with ART was found in registries of children with Beckwith-Wiedemann syndrome, Angelman syndrome, and retinoblastoma. Here, we review the epidemiology and molecular biology behind these studies and those of relevant model systems, and we highlight the need for investigation of two major questions: (1) large-scale case-control studies of ART outcomes, including long-term assessment of the incidence of birth defects and cancer, and (2) investigation of the relationship between epigenetic errors in both offspring and parents, the specific methods of ART used, and the underlying infertility diagnoses. In addition, the components of proprietary commercial media used in ART procedures must be fully and publicly disclosed, so that factors such as methionine content can be assessed, given the relationship in animal studies between methionine exposure and epigenetic changes. Twit Text FOAVip Epigenetics and assisted reproductive technology: a call for investigation ????Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=14991528 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=14991528 #FOAvip English Wikipedia <ref>{{Cite pmid|14991528}}</ref> Epigenetics and assisted reproductive technology: a call for investigation #MMPMID14991528 Niemitz EL; Feinberg AP Am J Hum Genet 2004[Apr]; 74 (4): 599-609 PMID14991528show ga A surprising set of recent observations suggests a link between assisted reproductive technology (ART) and epigenetic errors--that is, errors involving information other than DNA sequence that is heritable during cell division. An apparent association with ART was found in registries of children with Beckwith-Wiedemann syndrome, Angelman syndrome, and retinoblastoma. Here, we review the epidemiology and molecular biology behind these studies and those of relevant model systems, and we highlight the need for investigation of two major questions: (1) large-scale case-control studies of ART outcomes, including long-term assessment of the incidence of birth defects and cancer, and (2) investigation of the relationship between epigenetic errors in both offspring and parents, the specific methods of ART used, and the underlying infertility diagnoses. In addition, the components of proprietary commercial media used in ART procedures must be fully and publicly disclosed, so that factors such as methionine content can be assessed, given the relationship in animal studies between methionine exposure and epigenetic changes. |Angelman Syndrome/epidemiology/genetics[MESH] |Animal Husbandry[MESH] |Animals[MESH] |Beckwith-Wiedemann Syndrome/epidemiology/genetics[MESH] |Case-Control Studies[MESH] |Congenital Abnormalities/epidemiology/*etiology/*genetics[MESH] |Epigenesis, Genetic/*genetics[MESH] |Genetic Diseases, Inborn/epidemiology/*etiology/*genetics[MESH] |Humans[MESH] |Reproductive Techniques, Assisted/*adverse effects[MESH] |Retinoblastoma/epidemiology/genetics[MESH]Epigenetics and assisted reproductive technology: a call for investiga(epmc).pdf DeepDyve Pubget Overpricing