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suck abstract from ncbi


10.1016/0952-3278(92)90236-c

http://scihub22266oqcxt.onion/10.1016/0952-3278(92)90236-c
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1475272!?!1475272

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suck abstract from ncbi

pmid1475272      Prostaglandins+Leukot+Essent+Fatty+Acids 1992 ; 47 (3): 183-6
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  • In vivo and in vitro magnesium effects on aortic prostacyclin generation in DOCA-salt hypertensive rats #MMPMID1475272
  • Laurant P; Moussard C; Alber D; Henry JC; Berthelot A
  • Prostaglandins Leukot Essent Fatty Acids 1992[Nov]; 47 (3): 183-6 PMID1475272show ga
  • To investigate the blood pressure lowering effect of magnesium (Mg2+) in the hypertensive rat, we measured the prostacyclin release (PGI2, as immunoreactive 6-keto-PGF1 alpha) by isolated aortae from normotensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats fed a control or Mg(2+)-enriched diet. We also studied the in vitro effect of Mg2+ on aortic PGI2 release. The Mg(2+)-enriched diet significantly decreased by 10% blood pressure in DOCA-salt hypertensive rats but not in normotensive rats. The Mg(2+)-enriched diet significantly increased by 122% aortic PGI2 release in DOCA-salt hypertensive rats, but not in normotensive rats. Mg2+ supplementation in the incubation medium (4.8 mM) significantly increased aortic PGI2 release by 94% in DOCA-salt hypertensive rats, but not in normotensive rats. These data suggest that the Mg(2+)-induced attenuation of blood pressure in DOCA-salt hypertensive rats could be linked with the enhanced vascular PGI2 release.
  • |Animals[MESH]
  • |Aorta/*drug effects/metabolism[MESH]
  • |Blood Pressure/drug effects[MESH]
  • |Desoxycorticosterone[MESH]
  • |Epoprostenol/*biosynthesis/metabolism[MESH]
  • |Hypertension/chemically induced/*drug therapy/physiopathology[MESH]
  • |In Vitro Techniques[MESH]
  • |Magnesium/*pharmacology[MESH]
  • |Male[MESH]
  • |Rats[MESH]


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