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10.1016/j.jneuroim.2003.09.017

http://scihub22266oqcxt.onion/10.1016/j.jneuroim.2003.09.017
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14698845!ä!14698845

suck abstract from ncbi


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pmid14698845      J+Neuroimmunol 2004 ; 146 (1-2): 39-45
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  • Expression of interleukin-16 by microglial cells in inflammatory, autoimmune, and degenerative lesions of the rat brain #MMPMID14698845
  • Guo LH; Mittelbronn M; Brabeck C; Mueller CA; Schluesener HJ
  • J Neuroimmunol 2004[Jan]; 146 (1-2): 39-45 PMID14698845show ga
  • Here we report a comparative analysis of interleukin-16 (IL-16) expression by microglial cells of the normal rat brain in trimethyltin (TMT) neurotoxicity, experimental autoimmune uveitis (EAU), encephalomyelitis (EAE), and viral infection (Borna disease, Borna disease virus) by immunohistochemistry. Striking differences were observed. In contrast to the human brain, IL-16 was not expressed constitutively in the rat brain. Remote activation of microglial cells of the optic tract in EAU did not result into IL-16 expression. TMT intoxication induced expression in microglial cells of the hippocampus. In EAE and BDV, massive IL-16(+) microglial cells could be seen. Thus, IL-16 is a descriptor of microglial cell activation that discriminates between different disease models, and might be a valuable marker for the detection of microglia activation in human and rat central nervous system (CNS) diseases.
  • |Animals[MESH]
  • |Autoimmune Diseases/*immunology/metabolism/pathology[MESH]
  • |Borna Disease/immunology/metabolism/pathology[MESH]
  • |Brain/*immunology/metabolism/*pathology[MESH]
  • |Encephalomyelitis, Autoimmune, Experimental/immunology/metabolism/pathology[MESH]
  • |Gene Expression Regulation/physiology[MESH]
  • |Inflammation/immunology/metabolism[MESH]
  • |Interleukin-16/*biosynthesis/genetics[MESH]
  • |Microglia/*immunology/*metabolism[MESH]
  • |Nerve Degeneration/*immunology/metabolism/pathology[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Lew[MESH]
  • |Rats, Wistar[MESH]


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