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10.1016/S0002-9440(10)63593-6 http://scihub22266oqcxt.onion/10.1016/S0002-9440(10)63593-6 14633610/?report=reader!1892373!14633610     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=14633610&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 2003 ; 163 (6): 2383-95 Nephropedia Template TP {{tp|p=14633610|t=2003. Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans |pdf=|usr=}}{{14633610}} gab.com Text Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=14633610 #FOAvip Dermatofibrosarcoma protuberans (DFSP) is an aggressive spindle cell neoplasm. It is associated with the chromosomal translocation, t(17:22), which fuses the COL1A1 and PDGFbeta genes. We determined the characteristic gene expression profile of DFSP and characterized DNA copy number changes in DFSP by array-based comparative genomic hybridization (array CGH). Fresh frozen and formalin-fixed, paraffin-embedded samples of DFSP were analyzed by array CGH (four cases) and DNA microarray analysis of global gene expression (nine cases). The nine DFSPs were readily distinguished from 27 other diverse soft tissue tumors based on their gene expression patterns. Genes characteristically expressed in the DFSPs included PDGF beta and its receptor, PDGFRB, APOD, MEOX1, PLA2R, and PRKCA. Array CGH of DNA extracted either from frozen tumor samples or from paraffin blocks yielded equivalent results. Large areas of chromosomes 17q and 22q, bounded by COL1A1 and PDGF beta, respectively, were amplified in DFSP. Expression of genes in the amplified regions was significantly elevated. Our data shows that: 1) DFSP has a distinctive gene expression profile; 2) array CGH can be applied successfully to frozen or formalin-fixed, paraffin-embedded tumor samples; 3) a characteristic amplification of sequences from chromosomes 17q and 22q, demarcated by the COL1A1 and PDGF beta genes, respectively, was associated with elevated expression of the amplified genes. Twit Text FOAVip Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=14633610 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=14633610 #FOAvip English Wikipedia <ref>{{Cite pmid|14633610}}</ref> Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans #MMPMID14633610 Linn SC; West RB; Pollack JR; Zhu S; Hernandez-Boussard T; Nielsen TO; Rubin BP; Patel R; Goldblum JR; Siegmund D; Botstein D; Brown PO; Gilks CB; van de Rijn M Am J Pathol 2003[Dec]; 163 (6): 2383-95 PMID14633610show ga Dermatofibrosarcoma protuberans (DFSP) is an aggressive spindle cell neoplasm. It is associated with the chromosomal translocation, t(17:22), which fuses the COL1A1 and PDGFbeta genes. We determined the characteristic gene expression profile of DFSP and characterized DNA copy number changes in DFSP by array-based comparative genomic hybridization (array CGH). Fresh frozen and formalin-fixed, paraffin-embedded samples of DFSP were analyzed by array CGH (four cases) and DNA microarray analysis of global gene expression (nine cases). The nine DFSPs were readily distinguished from 27 other diverse soft tissue tumors based on their gene expression patterns. Genes characteristically expressed in the DFSPs included PDGF beta and its receptor, PDGFRB, APOD, MEOX1, PLA2R, and PRKCA. Array CGH of DNA extracted either from frozen tumor samples or from paraffin blocks yielded equivalent results. Large areas of chromosomes 17q and 22q, bounded by COL1A1 and PDGF beta, respectively, were amplified in DFSP. Expression of genes in the amplified regions was significantly elevated. Our data shows that: 1) DFSP has a distinctive gene expression profile; 2) array CGH can be applied successfully to frozen or formalin-fixed, paraffin-embedded tumor samples; 3) a characteristic amplification of sequences from chromosomes 17q and 22q, demarcated by the COL1A1 and PDGF beta genes, respectively, was associated with elevated expression of the amplified genes. |*Gene Dosage[MESH] |*Gene Expression Profiling[MESH] |Adult[MESH] |Aged[MESH] |Cryopreservation[MESH] |Dermatofibrosarcoma/*genetics/metabolism/pathology[MESH] |Female[MESH] |Fixatives[MESH] |Formaldehyde[MESH] |Gene Expression[MESH] |Humans[MESH] |Immunohistochemistry[MESH] |Male[MESH] |Middle Aged[MESH] |Nucleic Acid Hybridization[MESH] |Oligonucleotide Array Sequence Analysis[MESH] |Paraffin Embedding[MESH] |Skin Neoplasms/*genetics/metabolism/pathology[MESH]Gene expression patterns and gene copy number changes in dermatofibros(epmc).pdf DeepDyve Pubget Overpricing