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10.1128/JVI.66.8.4686-4692.1992 http://scihub22266oqcxt.onion/10.1128/JVI.66.8.4686-4692.1992 1385833!241293!1385833     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Virol 1992 ; 66 (8): 4686-92 Nephropedia Template TP {{tp|p=1385833|t=1992. A block in full-length transcript maturation in cells nonpermissive for B19 parvovirus |pdf=|usr=}}{{1385833}} gab.com Text A block in full-length transcript maturation in cells nonpermissive for B19 parvovirus JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=1385833 #FOAvip Vertebrate parvoviruses share a similar genomic organization, with the capsid proteins encoded by genes on the right side and nonstructural proteins encoded by genes on the left side. The temporal and cell-specific appearances of these two types of gene products are regulated by a variety of genetic mechanisms. Rodent parvovirus structural proteins, for example, are encoded by a separate promoter which is positively regulated by nonstructural-gene products. In contrast, for the human B19 parvovirus, the analogous structural-gene promoter is nonfunctional, and both left- and right-side transcripts originate from a single promoter and are highly processed. Using a combination of sensitive RNA analyses of wild-type and mutant templates, we have found that the relative abundance of these alternatively processed transcripts appears to be governed by unique postinitiation events. In permissive cells, the steady-state level of right-side structural-gene transcripts predominates over that of left-side nonstructural-gene transcripts. In nonpermissive cells transfected with the B19 virus genome, nonstructural-gene transcripts predominate. Removal of 3' processing signals located in the middle of the viral genome increases transcription of the far right side. Disruption of a polyadenylation signal in this region makes readthrough of full-length right-side transcripts possible. These results suggest that the abundance of B19 virus RNAs is determined by active 3' processing and is coupled to DNA template replication. Twit Text FOAVip A block in full-length transcript maturation in cells nonpermissive for B19 parvovirus ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=1385833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1385833 #FOAvip English Wikipedia <ref>{{Cite pmid|1385833}}</ref> A block in full-length transcript maturation in cells nonpermissive for B19 parvovirus #MMPMID1385833 Liu JM; Green SW; Shimada T; Young NS J Virol 1992[Aug]; 66 (8): 4686-92 PMID1385833show ga Vertebrate parvoviruses share a similar genomic organization, with the capsid proteins encoded by genes on the right side and nonstructural proteins encoded by genes on the left side. The temporal and cell-specific appearances of these two types of gene products are regulated by a variety of genetic mechanisms. Rodent parvovirus structural proteins, for example, are encoded by a separate promoter which is positively regulated by nonstructural-gene products. In contrast, for the human B19 parvovirus, the analogous structural-gene promoter is nonfunctional, and both left- and right-side transcripts originate from a single promoter and are highly processed. Using a combination of sensitive RNA analyses of wild-type and mutant templates, we have found that the relative abundance of these alternatively processed transcripts appears to be governed by unique postinitiation events. In permissive cells, the steady-state level of right-side structural-gene transcripts predominates over that of left-side nonstructural-gene transcripts. In nonpermissive cells transfected with the B19 virus genome, nonstructural-gene transcripts predominate. Removal of 3' processing signals located in the middle of the viral genome increases transcription of the far right side. Disruption of a polyadenylation signal in this region makes readthrough of full-length right-side transcripts possible. These results suggest that the abundance of B19 virus RNAs is determined by active 3' processing and is coupled to DNA template replication. |*DNA Replication[MESH] |Animals[MESH] |Base Sequence[MESH] |Blotting, Northern[MESH] |Capsid Proteins[MESH] |Capsid/*genetics[MESH] |Cell Line[MESH] |DNA, Viral/*genetics[MESH] |HeLa Cells[MESH] |Humans[MESH] |Molecular Sequence Data[MESH] |Mutagenesis, Site-Directed[MESH] |Oligodeoxyribonucleotides[MESH] |Oligonucleotides, Antisense[MESH] |Parvoviridae/*genetics/physiology[MESH] |Polymerase Chain Reaction/methods[MESH] |Promoter Regions, Genetic[MESH] |RNA, Viral/*genetics[MESH] |Restriction Mapping[MESH] |Templates, Genetic[MESH] |Transcription, Genetic[MESH] |Transfection[MESH] |Viral Core Proteins/*genetics[MESH]A block in full-length transcript maturation in cells nonpermissive fo(epmc).pdf DeepDyve Pubget Overpricing