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10.1016/s0895-7061(03)00987-7

http://scihub22266oqcxt.onion/10.1016/s0895-7061(03)00987-7
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12944025!ä!12944025

suck abstract from ncbi


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pmid12944025      Am+J+Hypertens 2003 ; 16 (9 Pt 1): 701-7
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  • Expression of the nuclear factor-kappaB and proto-oncogenes c-fos and c-jun are induced by low extracellular Mg2+ in aortic and cerebral vascular smooth muscle cells: possible links to hypertension, atherogenesis, and stroke #MMPMID12944025
  • Altura BM; Kostellow AB; Zhang A; Li W; Morrill GA; Gupta RK; Altura BT
  • Am J Hypertens 2003[Sep]; 16 (9 Pt 1): 701-7 PMID12944025show ga
  • Proto-oncogene (c-fos, c-jun) and nuclear factor-kappa B (NF-kappaB) expression, as well as DNA synthesis, in aortic and cerebral vascular smooth muscle cells (VSMCs) were upregulated by a decrease in extracellular magnesium ions ([Mg2+]o). Upregulation of these transcriptional factors was inversely proportional to the [Mg2+]o and occurred over the pathophysiologic range of serum Mg2+ found in patients presenting with hypertension, ischemic heart disease, and stroke. Removal of extracellular Ca2+ ([Ca2+]o), use of nifedipine or protein kinase C (PKC) inhibitors prevented the upregulation of the proto-oncogenes and DNA synthesis in VSMCs. These data show that [Mg2+]o may be an important, heretofore, overlooked natural modulator of proto-oncogene and NF-kappaB expression in VSMCs and that Ca2+ and PKC may play critical roles in induction of c-fos and c-jun in VSMCs induced by a decrease in [Mg2+]o. These results point to a role for low serum Mg2+ in potential development of hypertension, atherogenesis, vascular disease, and stroke.
  • |Animals[MESH]
  • |Aorta, Thoracic/*drug effects/*metabolism[MESH]
  • |Biomarkers/analysis[MESH]
  • |Calcium Channel Blockers/pharmacology[MESH]
  • |Calcium/metabolism/pharmacology[MESH]
  • |Cardiovascular Diseases[MESH]
  • |DNA/biosynthesis/drug effects[MESH]
  • |Disease Models, Animal[MESH]
  • |Dogs[MESH]
  • |Dose-Response Relationship, Drug[MESH]
  • |Enzyme Inhibitors/pharmacology[MESH]
  • |Extracellular Space/*metabolism[MESH]
  • |Genes, fos/*drug effects/*physiology[MESH]
  • |Genes, jun/*drug effects/*physiology[MESH]
  • |Hypertension/metabolism[MESH]
  • |Magnesium/*metabolism/*pharmacology[MESH]
  • |Male[MESH]
  • |Muscle, Smooth, Vascular/*cytology/*drug effects[MESH]
  • |Myocardial Ischemia/metabolism[MESH]
  • |Myocytes, Smooth Muscle/*drug effects/*metabolism[MESH]
  • |NF-kappa B/*biosynthesis/*drug effects[MESH]
  • |Nifedipine/pharmacology[MESH]
  • |Protein Kinase C/antagonists & inhibitors[MESH]
  • |RNA, Messenger/metabolism[MESH]
  • |Rats[MESH]
  • |Rats, Wistar[MESH]
  • |Stroke/metabolism[MESH]
  • |Telencephalon/*cytology/*drug effects[MESH]


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