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10.4049/jimmunol.171.3.1133 http://scihub22266oqcxt.onion/10.4049/jimmunol.171.3.1133 12874198!ä!12874198 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2003 ; 171 (3): 1133-9 Nephropedia Template TP {{tp|p=12874198|t=2003. Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice |pdf=|usr=}}{{12874198}} gab.com Text Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=12874198 #FOAvip A recombinant baculovirus expressing the hemagglutinin gene of the influenza virus, A/PR/8/34 (H1N1), under the control of the chicken beta-actin promoter, was constructed. To determine the induction of protective immunity in vivo, mice were inoculated with the recombinant baculovirus by intramuscular, intradermal, i.p., and intranasal routes and then were challenged with a lethal dose of the influenza virus. Intramuscular or i.p. immunization with the recombinant baculovirus elicited higher titers of antihemagglutinin Ab than intradermal or intranasal administration. However, protection from a lethal challenge of the influenza virus was only achieved by intranasal immunization of the recombinant baculovirus. Surprisingly, sufficient protection from the lethal influenza challenge was also observed in mice inoculated intranasally with a wild-type baculovirus, as evaluated by reductions in the virus titer, inflammatory cytokine production, and pulmonary consolidations. These results indicate that intranasal inoculation with a wild-type baculovirus induces a strong innate immune response, which protects mice from a lethal challenge of influenza virus. Twit Text FOAVip Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=12874198 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=12874198 #FOAvip English Wikipedia <ref>{{Cite pmid|12874198}}</ref> Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice #MMPMID12874198 Abe T; Takahashi H; Hamazaki H; Miyano-Kurosaki N; Matsuura Y; Takaku H J Immunol 2003[Aug]; 171 (3): 1133-9 PMID12874198show ga A recombinant baculovirus expressing the hemagglutinin gene of the influenza virus, A/PR/8/34 (H1N1), under the control of the chicken beta-actin promoter, was constructed. To determine the induction of protective immunity in vivo, mice were inoculated with the recombinant baculovirus by intramuscular, intradermal, i.p., and intranasal routes and then were challenged with a lethal dose of the influenza virus. Intramuscular or i.p. immunization with the recombinant baculovirus elicited higher titers of antihemagglutinin Ab than intradermal or intranasal administration. However, protection from a lethal challenge of the influenza virus was only achieved by intranasal immunization of the recombinant baculovirus. Surprisingly, sufficient protection from the lethal influenza challenge was also observed in mice inoculated intranasally with a wild-type baculovirus, as evaluated by reductions in the virus titer, inflammatory cytokine production, and pulmonary consolidations. These results indicate that intranasal inoculation with a wild-type baculovirus induces a strong innate immune response, which protects mice from a lethal challenge of influenza virus. |Administration, Intranasal[MESH] |Animals[MESH] |Cell Line[MESH] |Cytokines/biosynthesis[MESH] |Deoxyribonuclease I/chemistry[MESH] |Dogs[MESH] |Female[MESH] |Genetic Vectors[MESH] |Hemagglutinin Glycoproteins, Influenza Virus/biosynthesis/genetics/immunology[MESH] |Hot Temperature[MESH] |Humans[MESH] |Immunity, Innate/genetics[MESH] |Inflammation Mediators/metabolism[MESH] |Influenza A virus/genetics/immunology[MESH] |Influenza Vaccines/administration & dosage/genetics/immunology[MESH] |Influenza, Human/*immunology/mortality/pathology/*prevention & control[MESH] |Injections, Intramuscular[MESH] |Lung/immunology/pathology/virology[MESH] |Macrophage Activation/genetics[MESH] |Macrophages/immunology/metabolism[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Nucleopolyhedroviruses/genetics/*immunology[MESH] |Ribonuclease, Pancreatic/chemistry[MESH] |Tumor Cells, Cultured[MESH]Baculovirus induces an innate immune response and confers protection f(epmc).pdf DeepDyve Pubget Overpricing