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10.1152/ajprenal.00170.2003 http://scihub22266oqcxt.onion/10.1152/ajprenal.00170.2003 12865255!ä!12865255 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2003 ; 285 (5): F889-901 Nephropedia Template TP {{tp|p=12865255|t=2003. Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction |pdf=|usr=}}{{12865255}} gab.com Text Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=12865255 #FOAvip Urinary tract obstruction impairs urinary concentrating capacity and reabsorption of sodium. To clarify the molecular mechanisms of these defects, expression levels of renal sodium transporters were examined in rats with 24-h bilateral ureteral obstruction (BUO) or at day 3 or 14 after release of BUO (BUO-R). BUO resulted in downregulation of type 3 Na+/H+ exchanger (NHE3) to 41 +/- 14%, type 2 Na-Pi cotransporter (NaPi-2) to 26 +/- 6%, Na-K-ATPase to 67 +/- 8%, type 1 bumetanide-sensitive Na-K-2Cl cotransporter (BSC-1) to 20 +/- 7%, and thiazide-sensitive cotransporter (TSC) to 37 +/- 9%. Immunocytochemistry confirmed downregulation of NHE3, NaPi-2, Na-K-ATPase, BSC-1, and TSC. Consistent with this downregulation, BUO-R was associated with polyuria, reduced urinary osmolality, and increased urinary sodium and phosphate excretion. BUO-R for 3 days caused a persistant downregulation of NHE3 to 53 +/- 10%, NaPi-2 to 57 +/- 9%, Na-K-ATPase to 62 +/- 8%, BSC-1 to 50 +/- 12%, and TSC to 56 +/- 16%, which was associated with a marked reduction in the net renal reabsorption of sodium (616 +/- 54 vs. 944 +/- 24 micromol x min-1 x kg-1; P < 0.05) and phosphate (6.3 +/- 0.9 vs. 13.1 +/- 0.4 micromol x min-1. kg-1; P < 0.05) demonstrating a defect in renal sodium and phosphate reabsorption capacity. Moreover, downregulation of Na-K-ATPase and TSC persisted in BUO-R for 14 days, whereas NHE3, NaPi-2, and BSC-1 were normalized to control levels. In conclusion, downregulation of renal Na transporters in rats with BUO and release of BUO are likely to contribute to the associated urinary concentrating defect, increased urinary sodium excretion, and postobstructive polyuria. Twit Text FOAVip Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=12865255 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=12865255 #FOAvip English Wikipedia <ref>{{Cite pmid|12865255}}</ref> Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction #MMPMID12865255 Li C; Wang W; Kwon TH; Knepper MA; Nielsen S; Frokiaer J Am J Physiol Renal Physiol 2003[Nov]; 285 (5): F889-901 PMID12865255show ga Urinary tract obstruction impairs urinary concentrating capacity and reabsorption of sodium. To clarify the molecular mechanisms of these defects, expression levels of renal sodium transporters were examined in rats with 24-h bilateral ureteral obstruction (BUO) or at day 3 or 14 after release of BUO (BUO-R). BUO resulted in downregulation of type 3 Na+/H+ exchanger (NHE3) to 41 +/- 14%, type 2 Na-Pi cotransporter (NaPi-2) to 26 +/- 6%, Na-K-ATPase to 67 +/- 8%, type 1 bumetanide-sensitive Na-K-2Cl cotransporter (BSC-1) to 20 +/- 7%, and thiazide-sensitive cotransporter (TSC) to 37 +/- 9%. Immunocytochemistry confirmed downregulation of NHE3, NaPi-2, Na-K-ATPase, BSC-1, and TSC. Consistent with this downregulation, BUO-R was associated with polyuria, reduced urinary osmolality, and increased urinary sodium and phosphate excretion. BUO-R for 3 days caused a persistant downregulation of NHE3 to 53 +/- 10%, NaPi-2 to 57 +/- 9%, Na-K-ATPase to 62 +/- 8%, BSC-1 to 50 +/- 12%, and TSC to 56 +/- 16%, which was associated with a marked reduction in the net renal reabsorption of sodium (616 +/- 54 vs. 944 +/- 24 micromol x min-1 x kg-1; P < 0.05) and phosphate (6.3 +/- 0.9 vs. 13.1 +/- 0.4 micromol x min-1. kg-1; P < 0.05) demonstrating a defect in renal sodium and phosphate reabsorption capacity. Moreover, downregulation of Na-K-ATPase and TSC persisted in BUO-R for 14 days, whereas NHE3, NaPi-2, and BSC-1 were normalized to control levels. In conclusion, downregulation of renal Na transporters in rats with BUO and release of BUO are likely to contribute to the associated urinary concentrating defect, increased urinary sodium excretion, and postobstructive polyuria. |Animals[MESH] |Carrier Proteins/*metabolism[MESH] |Down-Regulation[MESH] |Kidney/*metabolism[MESH] |Male[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Receptors, Drug/metabolism[MESH] |Sodium Chloride Symporters[MESH] |Sodium-Hydrogen Exchanger 3[MESH] |Sodium-Hydrogen Exchangers/metabolism[MESH] |Sodium-Phosphate Cotransporter Proteins[MESH] |Sodium-Phosphate Cotransporter Proteins, Type I[MESH] |Sodium-Phosphate Cotransporter Proteins, Type II[MESH] |Sodium-Potassium-Chloride Symporters/metabolism[MESH] |Sodium-Potassium-Exchanging ATPase/metabolism[MESH] |Sodium/*metabolism[MESH] |Solute Carrier Family 12, Member 1[MESH] |Solute Carrier Family 12, Member 3[MESH] |Symporters/*metabolism[MESH] |Ureteral Obstruction/*metabolism[MESH]Altered expression of major renal Na transporters in rats with bilater(epmc).pdf DeepDyve Pubget Overpricing