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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biochem+Biophys+Res+Commun 2003 ; 306 (3): 718-24 Nephropedia Template TP
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The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters #MMPMID12810078
Wabakken T; Rian E; Kveine M; Aasheim HC
Biochem Biophys Res Commun 2003[Jul]; 306 (3): 718-24 PMID12810078show ga
We report here the first identification and structural characterization of a eukaryotic protein with homology to the bacterial MgtE family of potential Mg(2+) transporters. This human protein, denoted solute carrier family 41 member 1 (SLC41A1), consists of 513 amino acids with an estimated molecular weight of 56kDa. Computer analysis of the protein structure reveals that the protein consists of 10 putative transmembrane domains and includes two distinct domains highly homologous to the integral membrane part of the bacterial MgtE protein family. The gene encoding SLC41A1 is found on chromosome 1 (1q31-32) and the protein coding sequence is found on 10 exons. A 5-kb long transcript is identified in various human tissues with highest expression levels in heart and testis. We have also identified 10 SLC41A1 homologs in Homo sapiens, Mus musculus, Drosophila melanogaster, Anopheles gambiae, and Caenorhabditis elegans, and propose that these hypothetical proteins belong to a novel eukaryotic gene family.
|Amino Acid Sequence[MESH]
|Animals[MESH]
|Antiporters/genetics/*metabolism[MESH]
|Bacterial Proteins/genetics/*metabolism[MESH]
|Cation Transport Proteins[MESH]
|Cell Line[MESH]
|Chromosomes, Human, Pair 1[MESH]
|DNA, Complementary[MESH]
|Humans[MESH]
|Magnesium/*metabolism[MESH]
|Membrane Transport Proteins/chemistry/classification/genetics/*metabolism[MESH]