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suck abstract from ncbi

pmid12776780      Clin+Lab+Sci 2002 ; 15 (4): 208-12
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  • Clinical utility of the IRF: assessment of erythroid regeneration following parvo B19 infection #MMPMID12776780
  • Wyrick-Glatzel J; Conway-Klaassen J
  • Clin Lab Sci 2002[Fal]; 15 (4): 208-12 PMID12776780show ga
  • Parvo B19 (Fifth disease) is an erythrotropic virus which attaches through the 'P' globoside receptor on the surface of human red blood cells and precursors. This typically benign viral infection can cause a transient aplastic anemia in patients with underlying red cell disorders. In this case, a two-year-old child presents with severe aplastic anemia without evidence of underlying disease. Erythroid regeneration is monitored through the use of the immature reticulocyte fraction (IRF) and is demonstrated by the presence of high and medium fluorescence reticulocytes in the peripheral blood three to five days prior to the peak in absolute reticulocytes.
  • |*Parvovirus B19, Human[MESH]
  • |Anemia, Aplastic/*virology[MESH]
  • |Child, Preschool[MESH]
  • |Erythroid Precursor Cells/*metabolism/virology[MESH]
  • |Flow Cytometry/methods[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Parvoviridae Infections/*complications[MESH]
  • |Reticulocyte Count/methods[MESH]


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