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Reversal of systemic manifestations of cryoglobulinemia Treatment with melphalan and prednisone #MMPMID1267555
Ristow SC; Griner PF; Abraham GN; Shoulson I
Arch Intern Med 1976[Apr]; 136 (4): 467-70 PMID1267555show ga
In a patient with essential cryoglobulinemia with systemic, cutaneous, and neurologic manifestations and a mixed IgG-IgM cryoprotein, elimination of systemic and cutaneous disease manifestations, as well as notable reversal of neurologic impairment, followed therapy with melphalan. Levels of circulating cryoprotein decreased, but protein structure was unchanged by chemotherapy. Experience to date with alkylating agents suggests that this mode of treatment is the most effective currently available.