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suck abstract from ncbi

pmid1267555      Arch+Intern+Med 1976 ; 136 (4): 467-70
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  • Reversal of systemic manifestations of cryoglobulinemia Treatment with melphalan and prednisone #MMPMID1267555
  • Ristow SC; Griner PF; Abraham GN; Shoulson I
  • Arch Intern Med 1976[Apr]; 136 (4): 467-70 PMID1267555show ga
  • In a patient with essential cryoglobulinemia with systemic, cutaneous, and neurologic manifestations and a mixed IgG-IgM cryoprotein, elimination of systemic and cutaneous disease manifestations, as well as notable reversal of neurologic impairment, followed therapy with melphalan. Levels of circulating cryoprotein decreased, but protein structure was unchanged by chemotherapy. Experience to date with alkylating agents suggests that this mode of treatment is the most effective currently available.
  • |*Cryoglobulins[MESH]
  • |*Neurologic Manifestations[MESH]
  • |*Skin Manifestations[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*analysis[MESH]
  • |Immunoglobulin M/*analysis[MESH]
  • |Melphalan/*therapeutic use[MESH]
  • |Middle Aged[MESH]
  • |Paraproteinemias/*drug therapy[MESH]
  • |Prednisone/*therapeutic use[MESH]


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