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10.1093/hmg/ddg061 http://scihub22266oqcxt.onion/10.1093/hmg/ddg061 12668594!ä!12668594 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=12668594&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\12668594.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hum+Mol+Genet 2003 ; 12 Spec No 1 (ä): R27-35 Nephropedia Template TP {{tp|p=12668594|t=2003. To beat or not to beat: roles of cilia in development and disease |pdf=|usr=}}{{12668594}} gab.com Text To beat or not to beat: roles of cilia in development and disease JO: Hum Mol Genet http://www.kidney.de/pget.php?&tw=1&pmid=12668594 #FOAvip Cilia and flagella appeared very early in evolution to provide unicellular organisms with motility in water. Adaptation to non-aquatic life in plants resulted in the almost complete elimination of these organelles, except for gametic transport in some phylogenetic groups. In contrast, cilia and flagella were retained and employed for a wide variety of functions requiring fluid movement in complex multicellular animals. The functions of cilia in diverse processes such as left-right axis pattern formation, cerebrospinal fluid flow, sensory reception, mucociliary clearance and renal physiology indicate that cilia have been adapted as versatile tools for many biological processes. In this review, we discuss recent discoveries that have extended knowledge of the roles of cilia in normal development, and the pathological consequences caused by their dysfunction in mammals. We also consider evolutionary relationships between cilia from lower and higher eukaryotes, outline the ciliary components required for assembly and motility, and review the terminology of axonemal heavy chain dynein genes. Twit Text FOAVip To beat or not to beat: roles of cilia in development and disease ????Hum Mol Genet http://www.kidney.de/pget.php?&tw=1&pmid=12668594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=12668594 #FOAvip English Wikipedia <ref>{{Cite pmid|12668594}}</ref> To beat or not to beat: roles of cilia in development and disease #MMPMID12668594 Ibanez-Tallon I; Heintz N; Omran H Hum Mol Genet 2003[Apr]; 12 Spec No 1 (ä): R27-35 PMID12668594show ga Cilia and flagella appeared very early in evolution to provide unicellular organisms with motility in water. Adaptation to non-aquatic life in plants resulted in the almost complete elimination of these organelles, except for gametic transport in some phylogenetic groups. In contrast, cilia and flagella were retained and employed for a wide variety of functions requiring fluid movement in complex multicellular animals. The functions of cilia in diverse processes such as left-right axis pattern formation, cerebrospinal fluid flow, sensory reception, mucociliary clearance and renal physiology indicate that cilia have been adapted as versatile tools for many biological processes. In this review, we discuss recent discoveries that have extended knowledge of the roles of cilia in normal development, and the pathological consequences caused by their dysfunction in mammals. We also consider evolutionary relationships between cilia from lower and higher eukaryotes, outline the ciliary components required for assembly and motility, and review the terminology of axonemal heavy chain dynein genes. |Animals[MESH] |Body Patterning[MESH] |Cilia/*physiology/ultrastructure[MESH] |Cornea/physiology[MESH] |Dyneins/physiology[MESH] |Ependyma/physiology[MESH] |Fallopian Tube Diseases/pathology[MESH] |Female[MESH] |Flagella/physiology/ultrastructure[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Models, Anatomic[MESH] |Models, Biological[MESH]To beat or not to beat: roles of cilia in development and disease (epmc).pdf DeepDyve Pubget Overpricing