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10.1038/nm812

http://scihub22266oqcxt.onion/10.1038/nm812
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12496960!ä!12496960

suck abstract from ncbi


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pmid12496960      Nat+Med 2003 ; 9 (1): 53-60
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  • Human and porcine early kidney precursors as a new source for transplantation #MMPMID12496960
  • Dekel B; Burakova T; Arditti FD; Reich-Zeliger S; Milstein O; Aviel-Ronen S; Rechavi G; Friedman N; Kaminski N; Passwell JH; Reisner Y
  • Nat Med 2003[Jan]; 9 (1): 53-60 PMID12496960show ga
  • Kidney transplantation has been one of the major medical advances of the past 30 years. However, tissue availability remains a major obstacle. This can potentially be overcome by the use of undifferentiated or partially developed kidney precursor cells derived from early embryos and fetal tissue. Here, transplantation in mice reveals the earliest gestational time point at which kidney precursor cells, of both human and pig origin, differentiate into functional nephrons and not into other, non-renal professional cell types. Moreover, successful organogenesis is achieved when using the early kidney precursors, but not later-gestation kidneys. The formed, miniature kidneys are functional as evidenced by the dilute urine they produce. In addition, decreased immunogenicity of the transplants of early human and pig kidney precursors compared with adult kidney transplants is demonstrated in vivo. Our data pinpoint a window of human and pig kidney organogenesis that may be optimal for transplantation in humans.
  • |*Fetal Tissue Transplantation[MESH]
  • |*Organogenesis[MESH]
  • |Adult[MESH]
  • |Animals[MESH]
  • |CD3 Complex/immunology/metabolism[MESH]
  • |Gene Expression Regulation[MESH]
  • |Gestational Age[MESH]
  • |Humans[MESH]
  • |Kidney Transplantation/*methods[MESH]
  • |Kidney/anatomy & histology/*embryology/growth & development/physiology[MESH]
  • |Leukocytes, Mononuclear/immunology/metabolism[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Mice, SCID[MESH]
  • |Neovascularization, Physiologic[MESH]
  • |Oligonucleotide Array Sequence Analysis[MESH]
  • |Phylogeny[MESH]
  • |Platelet Endothelial Cell Adhesion Molecule-1/metabolism[MESH]
  • |Swine[MESH]
  • |Transplantation, Heterologous[MESH]


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