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10.4049/jimmunol.169.10.5673 http://scihub22266oqcxt.onion/10.4049/jimmunol.169.10.5673 12421946!ä!12421946 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2002 ; 169 (10): 5673-8 Nephropedia Template TP {{tp|p=12421946|t=2002. Regulation of virus-induced IL-12 and IL-23 expression in human macrophages |pdf=|usr=}}{{12421946}} gab.com Text Regulation of virus-induced IL-12 and IL-23 expression in human macrophages JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=12421946 #FOAvip IL-23 is a novel cytokine that promotes the proliferation of naive and memory T cells and stimulates their IFN-gamma production. Besides functional similarities, IL-23 bears structural resemblance to IL-12. Biologically active IL-23 is a heterodimer whose p40 subunit is identical to IL-12p40 while its p19 subunit is distantly related to IL-12p35. In the present study we demonstrate that human monocyte-derived macrophages are able to produce IL-23 in response to virus infection. Sendai virus stimulates the expression of p19 and p40 mRNAs in macrophages. Furthermore, it enhances p35 mRNA expression and the production of IL-12. Influenza A virus, in contrast, fails to stimulate IL-12 or IL-23 expression in macrophages. IL-12 and IL-23 contribute to the IFN-gamma-inducing activity that cell culture supernatant from Sendai virus-infected macrophages show in NK-92 cells. The induction of IFN-gamma production occurs in concert with IFN-alphabeta and IL-18, which are also secreted from the virus-infected cells. The IFN-gamma-inducing activity is inhibited by IL-4, which down-regulates the transcription of p19 and p40 genes and the secretion of IFN-alphabeta, IL-12, and IL-18. IFN-gamma, in contrast, up-regulates the p19 and p40 mRNA expression in Sendai virus infection. Thus, IL-4 and IFN-gamma serve as opposing factors in the regulation of IFN-gamma-inducing cytokines, including IL-23, in macrophages. Twit Text FOAVip Regulation of virus-induced IL-12 and IL-23 expression in human macrophages ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=12421946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=12421946 #FOAvip English Wikipedia <ref>{{Cite pmid|12421946}}</ref> Regulation of virus-induced IL-12 and IL-23 expression in human macrophages #MMPMID12421946 Pirhonen J; Matikainen S; Julkunen I J Immunol 2002[Nov]; 169 (10): 5673-8 PMID12421946show ga IL-23 is a novel cytokine that promotes the proliferation of naive and memory T cells and stimulates their IFN-gamma production. Besides functional similarities, IL-23 bears structural resemblance to IL-12. Biologically active IL-23 is a heterodimer whose p40 subunit is identical to IL-12p40 while its p19 subunit is distantly related to IL-12p35. In the present study we demonstrate that human monocyte-derived macrophages are able to produce IL-23 in response to virus infection. Sendai virus stimulates the expression of p19 and p40 mRNAs in macrophages. Furthermore, it enhances p35 mRNA expression and the production of IL-12. Influenza A virus, in contrast, fails to stimulate IL-12 or IL-23 expression in macrophages. IL-12 and IL-23 contribute to the IFN-gamma-inducing activity that cell culture supernatant from Sendai virus-infected macrophages show in NK-92 cells. The induction of IFN-gamma production occurs in concert with IFN-alphabeta and IL-18, which are also secreted from the virus-infected cells. The IFN-gamma-inducing activity is inhibited by IL-4, which down-regulates the transcription of p19 and p40 genes and the secretion of IFN-alphabeta, IL-12, and IL-18. IFN-gamma, in contrast, up-regulates the p19 and p40 mRNA expression in Sendai virus infection. Thus, IL-4 and IFN-gamma serve as opposing factors in the regulation of IFN-gamma-inducing cytokines, including IL-23, in macrophages. |Cell Line[MESH] |Cells, Cultured[MESH] |Cytokines/antagonists & inhibitors/biosynthesis/physiology[MESH] |Down-Regulation/genetics/immunology[MESH] |Gene Expression Regulation, Viral/*immunology[MESH] |Humans[MESH] |Influenza A virus/*immunology[MESH] |Interferon-gamma/biosynthesis/physiology[MESH] |Interleukin-12 Subunit p35[MESH] |Interleukin-12 Subunit p40[MESH] |Interleukin-12/*biosynthesis/genetics[MESH] |Interleukin-23[MESH] |Interleukin-23 Subunit p19[MESH] |Interleukin-4/pharmacology[MESH] |Interleukins/*biosynthesis/genetics[MESH] |Killer Cells, Natural/immunology/metabolism[MESH] |Macrophages/*immunology/metabolism/*virology[MESH] |Protein Subunits/biosynthesis/genetics[MESH] |RNA, Messenger/biosynthesis[MESH] |Sendai virus/*immunology[MESH] |Tumor Cells, Cultured[MESH]Regulation of virus-induced IL-12 and IL-23 expression in human macrop(epmc).pdf DeepDyve Pubget Overpricing