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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Dev+Biol 2002 ; 46 (4): 535-44 Nephropedia Template TP
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PAX genes in development and disease: the role of PAX2 in urogenital tract development #MMPMID12141441
Eccles MR; He S; Legge M; Kumar R; Fox J; Zhou C; French M; Tsai RW
Int J Dev Biol 2002[]; 46 (4): 535-44 PMID12141441show ga
PAX genes play an important role in fetal development. Moreover, heterozygous mutations in several PAX genes cause human disease. Here we review the role of PAX2 in kidney development, focusing on the morphological effects of PAX2 mutations. We discuss the role of PAX2 in the context of an inhibitory field model of kidney branching morphogenesis and summarize recent progress in this area.