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Successful treatment by cyclooxyenase-2 inhibitor of refractory hypokalemia in a patient with Gitelman s syndrome #MMPMID12141411
Mayan H; Gurevitz O; Farfel Z
Clin Nephrol 2002[Jul]; 58 (1): 73-6 PMID12141411show ga
Gitelman's syndrome is manifested by hypokalemic alkalosis, hypomagnesemia, hypocalciuria, normotensive hyperreninemia and hyperaldosteronism. Hypokalemia can at times be refractory to treatment. We present a patient refractory to a variety of drugs including indomethacin, the nonspecific COX inhibitor. Rofecoxib, a specific COX 2 inhibitor, promptly elevated serum potassium concentration with normalization of plasma aldosterone and near normalization of renin without a change in serum magnesium. Our patient also had rhabdomyolysis, a rarely reported complication, which was also ameliorated by COX 2 inhibition.