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10.5414/cnp58073

http://scihub22266oqcxt.onion/10.5414/cnp58073
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12141411!?!12141411

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suck abstract from ncbi

pmid12141411      Clin+Nephrol 2002 ; 58 (1): 73-6
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  • Successful treatment by cyclooxyenase-2 inhibitor of refractory hypokalemia in a patient with Gitelman s syndrome #MMPMID12141411
  • Mayan H; Gurevitz O; Farfel Z
  • Clin Nephrol 2002[Jul]; 58 (1): 73-6 PMID12141411show ga
  • Gitelman's syndrome is manifested by hypokalemic alkalosis, hypomagnesemia, hypocalciuria, normotensive hyperreninemia and hyperaldosteronism. Hypokalemia can at times be refractory to treatment. We present a patient refractory to a variety of drugs including indomethacin, the nonspecific COX inhibitor. Rofecoxib, a specific COX 2 inhibitor, promptly elevated serum potassium concentration with normalization of plasma aldosterone and near normalization of renin without a change in serum magnesium. Our patient also had rhabdomyolysis, a rarely reported complication, which was also ameliorated by COX 2 inhibition.
  • |Adult[MESH]
  • |Alkalosis/drug therapy[MESH]
  • |Calcium/urine[MESH]
  • |Cyclooxygenase Inhibitors/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Hyperaldosteronism[MESH]
  • |Hypokalemia/diagnosis/*drug therapy[MESH]
  • |Lactones/*therapeutic use[MESH]
  • |Magnesium/blood[MESH]
  • |Male[MESH]
  • |Rhabdomyolysis/diagnosis/*drug therapy[MESH]
  • |Sulfones[MESH]
  • |Syndrome[MESH]


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