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10.1128/AAC.46.7.2287-2291.2002

http://scihub22266oqcxt.onion/10.1128/AAC.46.7.2287-2291.2002
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suck abstract from ncbi


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pmid12069992      Antimicrob+Agents+Chemother 2002 ; 46 (7): 2287-91
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  • Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats #MMPMID12069992
  • Solbrig MV; Schlaberg R; Briese T; Horscroft N; Lipkin WI
  • Antimicrob Agents Chemother 2002[Jul]; 46 (7): 2287-91 PMID12069992show ga
  • In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1beta (IL-1beta), IL-10, and gamma interferon in the brain. Intracerebral ribavirin may reduce morbidity through effects on microglia cell proliferation.
  • |Animals[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Borna Disease/*drug therapy/immunology/pathology[MESH]
  • |Borna disease virus/immunology[MESH]
  • |Brain/metabolism/virology[MESH]
  • |Cell Division/drug effects[MESH]
  • |Cytokines/genetics[MESH]
  • |Male[MESH]
  • |Microglia/cytology/*drug effects[MESH]
  • |Neuroprotective Agents/*therapeutic use[MESH]
  • |RNA, Messenger/analysis[MESH]
  • |RNA, Viral/analysis[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Lew[MESH]
  • |Ribavirin/pharmacokinetics/*therapeutic use[MESH]


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