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10.1016/S0006-291X(02)00542-9 http://scihub22266oqcxt.onion/10.1016/S0006-291X(02)00542-9 12056828!ä!12056828 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2002 ; 294 (3): 710-3 Nephropedia Template TP {{tp|p=12056828|t=2002. Magnesium influx enhanced by nitric oxide in hypertensive rat proximal tubule cells |pdf=|usr=}}{{12056828}} gab.com Text Magnesium influx enhanced by nitric oxide in hypertensive rat proximal tubule cells JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=12056828 #FOAvip An abnormal handling of renal magnesium has been suggested to cause salt-sensitive hypertension. The filtered magnesium is first reabsorbed in the proximal tubule. Amiloride has been shown to enhance renal magnesium conservation, but the regulatory mechanisms are unknown yet. High-salt (8% NaCl) diet decreased serum magnesium concentration, while increased urinary magnesium in Dahl salt-sensitive (DS) rat. Furthermore, the expression of nitric oxide synthase type 3 and nitric oxide (NO) content were decreased in high-salt loaded DS rat. In isolated proximal tubule cells, amiloride (0.1 mM) increased intracellular free magnesium concentration ([Mg(2+)](i)). However, the net [Mg(2+)](i) increase in the high-salt loaded DS rat was smaller than other groups. NOR1 (0.1 mM), a NO donor, restored the increase of [Mg(2+)](i) to the same level of other groups. On the contrary, L-NMMA (0.1 mM), an inhibitor of NO production, inhibited the increase of [Mg(2+)](i) in all groups. These results suggest that intracellular NO has an important role to up-regulate amiloride-elicited magnesium influx. Twit Text FOAVip Magnesium influx enhanced by nitric oxide in hypertensive rat proximal tubule cells ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=12056828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=12056828 #FOAvip English Wikipedia <ref>{{Cite pmid|12056828}}</ref> Magnesium influx enhanced by nitric oxide in hypertensive rat proximal tubule cells #MMPMID12056828 Ikari A; Kano T; Suketa Y Biochem Biophys Res Commun 2002[Jun]; 294 (3): 710-3 PMID12056828show ga An abnormal handling of renal magnesium has been suggested to cause salt-sensitive hypertension. The filtered magnesium is first reabsorbed in the proximal tubule. Amiloride has been shown to enhance renal magnesium conservation, but the regulatory mechanisms are unknown yet. High-salt (8% NaCl) diet decreased serum magnesium concentration, while increased urinary magnesium in Dahl salt-sensitive (DS) rat. Furthermore, the expression of nitric oxide synthase type 3 and nitric oxide (NO) content were decreased in high-salt loaded DS rat. In isolated proximal tubule cells, amiloride (0.1 mM) increased intracellular free magnesium concentration ([Mg(2+)](i)). However, the net [Mg(2+)](i) increase in the high-salt loaded DS rat was smaller than other groups. NOR1 (0.1 mM), a NO donor, restored the increase of [Mg(2+)](i) to the same level of other groups. On the contrary, L-NMMA (0.1 mM), an inhibitor of NO production, inhibited the increase of [Mg(2+)](i) in all groups. These results suggest that intracellular NO has an important role to up-regulate amiloride-elicited magnesium influx. |Animals[MESH] |Biological Transport/drug effects[MESH] |Enzyme Inhibitors/pharmacology[MESH] |Hypertension/*metabolism[MESH] |In Vitro Techniques[MESH] |Kidney Tubules, Proximal/*metabolism[MESH] |Magnesium/*metabolism[MESH] |Male[MESH] |Nitric Oxide/*metabolism[MESH] |Rats[MESH] |Rats, Inbred Dahl[MESH]Magnesium influx enhanced by nitric oxide in hypertensive rat proximal(epmc).pdf DeepDyve Pubget Overpricing