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10.1002/cncr.10502

http://scihub22266oqcxt.onion/10.1002/cncr.10502
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12015773!ä!12015773

suck abstract from ncbi


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pmid12015773      Cancer 2002 ; 94 (9): 2474-80
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  • Outcome of suprarenal localized masses diagnosed during the perinatal period: a retrospective multicenter study #MMPMID12015773
  • Sauvat F; Sarnacki S; Brisse H; Medioni J; Rubie H; Aigrain Y; Gauthier F; Audry G; Helardot P; Landais P; Michon J; Hartmann O; Nihoul-Fekete C
  • Cancer 2002[May]; 94 (9): 2474-80 PMID12015773show ga
  • BACKGROUND: The growing use of abdominal ultrasonography during pregnancy and in the postnatal period is leading to the discovery of an increasing number of suprarenal masses. The optimal diagnosis and treatment of these masses has not yet been determined. METHODS: The authors reviewed the files of patients with suprarenal masses detected prenatally or during the first 3 months of life, between 1986 and 1999, in the pediatric surgery and oncology departments of Paris hospitals. RESULTS: Thirty masses were detected prenatally and 23 postnatally. In the latter group of patients, the diagnosis was based on ultrasound in 8 cases and on the palpation of a mass in 15 cases, 13 of which were neuroblastoma. At birth, the masses were cystic in 19 cases, solid in 17, and mixed in 13. Sensitivities of methyliodobenzylguanidine and urinary catecholamine assay were 70% and 52% respectively. Surgery was performed in 38 cases with a median age of 42 days. Histologic analysis showed 31 neuroblastomas, 1 adrenal hemorrhage, 2 necrotic masses, 1 bronchogenic cyst, and 3 sequestrations. All the patients were alive and disease free, at a follow-up ranging from 3 months to 13 years. CONCLUSIONS: In this series, 58% of the suprarenal masses diagnosed perinatally were localized neuroblastoma with a favorable outcome. All other cases either regressed spontaneously or turned out to be benign lesion. Thus, the management of these masses must strike a compromise between aggressive treatment and a wait-and-see attitude. This requires appropriate initial assessment and a close follow-up in a specialized center.
  • |Adrenal Gland Neoplasms/*diagnosis/diagnostic imaging/surgery[MESH]
  • |Catecholamines/urine[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Magnetic Resonance Imaging[MESH]
  • |Neuroblastoma/*diagnosis/diagnostic imaging/surgery[MESH]
  • |Pregnancy[MESH]
  • |Retrospective Studies[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Tomography, X-Ray Computed[MESH]
  • |Treatment Outcome[MESH]


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