Alterations moleculaires primaires et troubles biologiques secondaires des syndromes de Bartter et de Gitelman #MMPMID11998428
Deschenes G; Feldmann D; Doucet A
Arch Pediatr 2002[Apr]; 9 (4): 406-16 PMID11998428show ga
Bartter syndrome and Gitelman syndrome are primary hereditary diseases characterized by hypokaliemia, alkalosis, hypertrophy of the juxtaglomerular complex with secondary hyperaldoteronism and normal blood pressure. They result from molecular disorders leading to a defect of sodium reabsorption in respectively the Henle's loop and the distal convoluted tubule. Biological adaptations of downstream tubular segments, i.e. distal convoluted tubule and collecting duct, are responsible for hypokaliemia, alkalosis, renin-aldosterone activation, prostaglandins hypersecretion and dysregulation of the urinary excretion of calcium and magnesium, illustrating the close integration of the regulation of different solutes in the distal tubular structures.
Arch+Pediatr 2002 ; 9 (4): 406-16
