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10.1002/jmv.2217

http://scihub22266oqcxt.onion/10.1002/jmv.2217
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11992589!ä!11992589

suck abstract from ncbi


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pmid11992589      J+Med+Virol 2002 ; 67 (2): 267-74
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  • Parvovirus B19 nonstructural (NS1) protein as a transactivator of interleukin-6 synthesis: common pathway in inflammatory sequelae of human parvovirus infections? #MMPMID11992589
  • Mitchell LA
  • J Med Virol 2002[Jun]; 67 (2): 267-74 PMID11992589show ga
  • This review focuses on the role that human parvovirus B19 nonstructural (NS1) protein as a transactivator of the proinflammatory cytokine, interleukin-6 (IL-6), might play in triggering the multiparametric inflammatory outcomes of B19 infection. Parvovirus B19 is a ubiquitous virus, and it is often expressed during conditions of immunodepression including that induced by long-term chemotherapy, viral infection (HIV, HTLV-1), or genetic immunodeficiency disorders. Through NS1 expression, B19 may contribute to the immune dysregulation associated with these disorders, or serve as a cofactor in enhancing retroviral replication. Hence, NS1 transactivation of proinflammatory cytokine promoters such as IL-6 may be pivotal in triggering the various inflammatory and autoimmune disorders that have been linked to parvovirus B19 infections.
  • |*Transcriptional Activation[MESH]
  • |Arthritis/immunology/physiopathology[MESH]
  • |Autoimmune Diseases/immunology/physiopathology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Inflammation/immunology/*physiopathology[MESH]
  • |Interleukin-6/*biosynthesis/genetics[MESH]
  • |Parvoviridae Infections/immunology/*physiopathology/virology[MESH]
  • |Parvovirus B19, Human/immunology/*physiology[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Complications, Infectious/immunology/physiopathology/virology[MESH]


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