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10.1016/s0278-6915(01)00131-4

http://scihub22266oqcxt.onion/10.1016/s0278-6915(01)00131-4
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11955673!ä!11955673

suck abstract from ncbi


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pmid11955673      Food+Chem+Toxicol 2002 ; 40 (5): 669-72
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  • Effect of aflatoxins on testicular steroidogenesis and amelioration by vitamin E #MMPMID11955673
  • Verma RJ; Nair A
  • Food Chem Toxicol 2002[May]; 40 (5): 669-72 PMID11955673show ga
  • The potential of aflatoxin to affect testicular steroidogenesis and its amelioration by vitamin E was assessed in the present investigation. Oral administration of aflatoxin (25 and 50 microg/animal/day) for 45 days to adult mice caused, as compared with control, a dose-dependent significant rise in cholesterol content. However, the activities of 3beta- and 17beta-hydroxysteroid dehydrogenases and serum testosterone levels were significantly reduced in aflatoxin-treated mice as compared with the controls. Pretreatment with vitamin E (2 mg/animal/day, orally) significantly ameliorated aflatoxin-induced changes as compared with aflatoxin treatment alone. The present investigation clearly indicates that vitamin E ameliorates aflatoxin-induced changes in steroidogenesis.
  • |17-Hydroxysteroid Dehydrogenases/metabolism[MESH]
  • |3-Hydroxysteroid Dehydrogenases/metabolism[MESH]
  • |Aflatoxins/*antagonists & inhibitors/*toxicity[MESH]
  • |Animals[MESH]
  • |Antioxidants/*pharmacology[MESH]
  • |Aspergillus/chemistry[MESH]
  • |Behavior, Animal/drug effects[MESH]
  • |Carcinogens/*toxicity[MESH]
  • |Cholesterol/blood[MESH]
  • |Dose-Response Relationship, Drug[MESH]
  • |Lethal Dose 50[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Steroids/*biosynthesis[MESH]
  • |Testis/drug effects/enzymology/*metabolism[MESH]
  • |Testosterone/biosynthesis/blood[MESH]


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