Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1086/338931 http://scihub22266oqcxt.onion/10.1086/338931 11836650/?report=reader!384951!11836650     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Hum+Genet 2002 ; 70 (3): 751-7 Nephropedia Template TP {{tp|p=11836650|t=2002. Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting |pdf=|usr=}}{{11836650}} gab.com Text Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting JO: Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=11836650 #FOAvip Some genes that affect development and behavior in mammals are known to be imprinted; and > or = 1% of all mammalian genes are imprinted. Hence, incorporating an imprinting parameter into linkage analysis may increase the power to detect linkage for these traits. Here we propose theoretical justifications for a recently developed model for testing of linkage, in the presence of genetic imprinting, between a quantitative-trait locus and a polymorphic marker; this is achieved in the variance-components framework. We also incorporate sex-specific recombination fractions into this model. We discuss the effects that imprinting and nonimprinting have on the power of the usual variance-components method and on the variance-components method that incorporates an imprinting parameter. We provide noncentrality parameters that can be used to determine the sample size necessary to attain a specified power for a given significance level, which is useful in the planning of a linkage study. Optimal strategies for a genome scan of potentially imprinted traits are discussed. Twit Text FOAVip Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting ????Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=11836650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11836650 #FOAvip English Wikipedia <ref>{{Cite pmid|11836650}}</ref> Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting #MMPMID11836650 Shete S; Amos CI Am J Hum Genet 2002[Mar]; 70 (3): 751-7 PMID11836650show ga Some genes that affect development and behavior in mammals are known to be imprinted; and > or = 1% of all mammalian genes are imprinted. Hence, incorporating an imprinting parameter into linkage analysis may increase the power to detect linkage for these traits. Here we propose theoretical justifications for a recently developed model for testing of linkage, in the presence of genetic imprinting, between a quantitative-trait locus and a polymorphic marker; this is achieved in the variance-components framework. We also incorporate sex-specific recombination fractions into this model. We discuss the effects that imprinting and nonimprinting have on the power of the usual variance-components method and on the variance-components method that incorporates an imprinting parameter. We provide noncentrality parameters that can be used to determine the sample size necessary to attain a specified power for a given significance level, which is useful in the planning of a linkage study. Optimal strategies for a genome scan of potentially imprinted traits are discussed. |Alleles[MESH] |Chromosome Mapping/*methods/statistics & numerical data[MESH] |Female[MESH] |Genome, Human[MESH] |Genomic Imprinting/*genetics[MESH] |Genotype[MESH] |Humans[MESH] |Lod Score[MESH] |Male[MESH] |Polymorphism, Genetic/genetics[MESH] |Probability[MESH] |Quantitative Trait, Heritable[MESH] |Recombination, Genetic/genetics[MESH]Testing for genetic linkage in families by a variance-components appro(epmc).pdf DeepDyve Pubget Overpricing