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10.2741/A793

http://scihub22266oqcxt.onion/10.2741/A793
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11815301!ä!11815301

suck abstract from ncbi


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pmid11815301      Front+Biosci 2002 ; 7 (ä): d541-55
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  • The immunopathogenesis of Borna disease virus infection #MMPMID11815301
  • Stitz L; Bilzer T; Planz O
  • Front Biosci 2002[Feb]; 7 (ä): d541-55 PMID11815301show ga
  • Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system. The single-stranded RNA Borna disease virus, a member of Bornaviridae in the order of Mononegavirale, lacks cytopathogenicity both in vitro and in vivo. After experimental infection BDV causes a persistent infection of the central nervous system and induces Borna disease, an immune-mediated encephalomyelitis. The infiltrating immune cells have been characterized as CD4-positive, CD8-positive T-cells, macrophages and B cells. CD8-positive T cells represent the effector cell population exhibiting antigen specificity for the nucleoprotein.
  • |Animals[MESH]
  • |Borna Disease/*immunology/pathology/virology[MESH]
  • |Borna disease virus/immunology/pathogenicity[MESH]
  • |CD4-Positive T-Lymphocytes/immunology[MESH]
  • |Cytokines/biosynthesis[MESH]
  • |Models, Immunological[MESH]
  • |Rats[MESH]


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