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10.1152/ajprenal.0085.2001 http://scihub22266oqcxt.onion/10.1152/ajprenal.0085.2001 11704552!ä!11704552 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2001 ; 281 (6): F1021-7 Nephropedia Template TP {{tp|p=11704552|t=2001. Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron |pdf=|usr=}}{{11704552}} gab.com Text Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=11704552 #FOAvip The organization of Na(+) and Ca(2+) transport pathways along the mouse distal nephron is incompletely known. We revealed by immunohistochemistry a set of Ca(2+) and Na(+) transport proteins along the mouse distal convolution. The thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC) characterized the distal convoluted tubule (DCT). The amiloride-sensitive epithelial Na(+) channel (ENaC) colocalized with NCC in late DCT (DCT2) and extended to the downstream connecting tubule (CNT) and collecting duct (CD). In early DCT (DCT1), the basolateral Ca(2+)-extruding proteins [Na(+)/Ca(2+) exchanger (NCX), plasma membrane Ca(2+)-ATPase (PCMA)] and the cytoplasmic Ca(2+)-binding protein calbindin D(28K) (CB) were found at very low levels, whereas the cytoplasmic Ca(2+)/Mg(2+)-binding protein parvalbumin was highly abundant. NCX, PMCA, and CB prevailed in DCT2 and CNT, where we located the apical epithelial Ca(2+) channel (ECaC1). Its subcellular localization changed from apical in DCT2 to exclusively cytoplasmic at the end of CNT. NCX and PMCA decreased in parallel with the fading of ECaC1 in the apical membrane. All three of them were undetectable in CD. These findings disclose DCT2 and CNT as major sites for transcellular Ca(2+) transport in the mouse distal nephron. Cellular colocalization of Ca(2+) and Na(+) transport pathways suggests their mutual interactions in transport regulation. Twit Text FOAVip Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=11704552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11704552 #FOAvip English Wikipedia <ref>{{Cite pmid|11704552}}</ref> Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron #MMPMID11704552 Loffing J; Loffing-Cueni D; Valderrabano V; Klausli L; Hebert SC; Rossier BC; Hoenderop JG; Bindels RJ; Kaissling B Am J Physiol Renal Physiol 2001[Dec]; 281 (6): F1021-7 PMID11704552show ga The organization of Na(+) and Ca(2+) transport pathways along the mouse distal nephron is incompletely known. We revealed by immunohistochemistry a set of Ca(2+) and Na(+) transport proteins along the mouse distal convolution. The thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC) characterized the distal convoluted tubule (DCT). The amiloride-sensitive epithelial Na(+) channel (ENaC) colocalized with NCC in late DCT (DCT2) and extended to the downstream connecting tubule (CNT) and collecting duct (CD). In early DCT (DCT1), the basolateral Ca(2+)-extruding proteins [Na(+)/Ca(2+) exchanger (NCX), plasma membrane Ca(2+)-ATPase (PCMA)] and the cytoplasmic Ca(2+)-binding protein calbindin D(28K) (CB) were found at very low levels, whereas the cytoplasmic Ca(2+)/Mg(2+)-binding protein parvalbumin was highly abundant. NCX, PMCA, and CB prevailed in DCT2 and CNT, where we located the apical epithelial Ca(2+) channel (ECaC1). Its subcellular localization changed from apical in DCT2 to exclusively cytoplasmic at the end of CNT. NCX and PMCA decreased in parallel with the fading of ECaC1 in the apical membrane. All three of them were undetectable in CD. These findings disclose DCT2 and CNT as major sites for transcellular Ca(2+) transport in the mouse distal nephron. Cellular colocalization of Ca(2+) and Na(+) transport pathways suggests their mutual interactions in transport regulation. |*Receptors, Drug[MESH] |*Symporters[MESH] |Animals[MESH] |Calbindins[MESH] |Calcium Channels/analysis/immunology[MESH] |Calcium-Transporting ATPases/analysis/immunology[MESH] |Calcium/*metabolism[MESH] |Carrier Proteins/*analysis/immunology[MESH] |Cation Transport Proteins[MESH] |Epithelial Sodium Channels[MESH] |Female[MESH] |Immunohistochemistry[MESH] |Ion Transport[MESH] |Kidney Tubules, Distal/chemistry/*metabolism[MESH] |Mice[MESH] |Models, Biological[MESH] |Parvalbumins/analysis/immunology[MESH] |Plasma Membrane Calcium-Transporting ATPases[MESH] |S100 Calcium Binding Protein G/analysis/immunology[MESH] |Sodium Channels/analysis/immunology[MESH] |Sodium Chloride Symporters[MESH] |Sodium-Calcium Exchanger/analysis/immunology[MESH] |Sodium/*metabolism[MESH] |Solute Carrier Family 12, Member 3[MESH]Distribution of transcellular calcium and sodium transport pathways al(epmc).pdf DeepDyve Pubget Overpricing