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10.1086/324502

http://scihub22266oqcxt.onion/10.1086/324502
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11698988!ä!11698988

suck abstract from ncbi


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pmid11698988      Clin+Infect+Dis 2001 ; 33 (12): 2040-8
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  • Acquired disorders of phagocyte function complicating medical and surgical illnesses #MMPMID11698988
  • Engelich G; Wright DG; Hartshorn KL
  • Clin Infect Dis 2001[Dec]; 33 (12): 2040-8 PMID11698988show ga
  • There is evidence that acquired dysfunction of neutrophils, monocytes, or macrophages is an important cause of infection in patients with diabetes mellitus, renal or hepatic failure, alcoholism, autoimmune diseases, influenza or human immunodeficiency virus infection, burns, and trauma. Distinguishable mechanisms of acquired phagocyte dysfunction include inhibitory effects of metabolic disturbances (e.g., hyperglycemia, uremia), chemical toxins (e.g., ethanol), viral proteins on phagocyte activation, and pathologic activation of phagocytes in the circulation (e.g., after hemodialysis, burns, or cardiopulmonary bypass). Although the burden of morbidity and mortality resulting from acquired phagocyte dysfunction appears to be vast, research in this area has been hampered by the complexity of the underlying illnesses and by limitations of laboratory assays and clinical study methodology. Given the advent of improved assays of phagocyte functions and treatments that can enhance these functions, there is a pressing need for more prospective studies of acquired phagocyte dysfunction.
  • |Alcoholism/etiology[MESH]
  • |Autoimmune Diseases/etiology[MESH]
  • |Burns/etiology[MESH]
  • |Diabetes Mellitus/etiology[MESH]
  • |HIV[MESH]
  • |Humans[MESH]
  • |Liver Cirrhosis/etiology[MESH]
  • |Metabolic Diseases/*etiology[MESH]
  • |Orthomyxoviridae[MESH]
  • |Phagocyte Bactericidal Dysfunction/*complications[MESH]
  • |Renal Insufficiency/etiology[MESH]


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