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10.1016/S0006-3495(01)75853-5 http://scihub22266oqcxt.onion/10.1016/S0006-3495(01)75853-5 11566776!1301677!11566776     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+J 2001 ; 81 (4): 2035-49 Nephropedia Template TP {{tp|p=11566776|t=2001. Unitary conductance variation in Kir2 1 and in cardiac inward rectifier potassium channels |pdf=|usr=}}{{11566776}} gab.com Text Unitary conductance variation in Kir2 1 and in cardiac inward rectifier potassium channels JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=11566776 #FOAvip Kir2.1 (IRK1) is the complementary DNA for a component of a cardiac inwardly rectifying potassium channel. When Kir2.1 is expressed in Xenopus oocytes or human embryonic kidney (HEK) cells (150 mM external KCl), the unitary conductances form a broad distribution, ranging from 2 to 33 pS. Channels with a similarly broad distribution of unitary conductance amplitudes are also observed in recordings from adult mouse cardiac myocytes under similar experimental conditions. In all three cell types channels with conductances smaller, and occasionally larger, than the ~30 pS ones are found in the same patches as the ~30 pS openings, or in patches by themselves. The unitary conductances in patches with a single active channel are stable for the durations of the recordings. Channels of all amplitudes share several biophysical characteristics, including inward rectification, voltage sensitivity of open probability, sensitivity of open probability to external divalent cations, shape of the open channel i-V relation, and Cs(+) block. The only biophysical difference found between large and small conductance channels is that the rate constant for Cs(+) block is reduced for the small-amplitude channels. The unblocking rate constant is similar for channels of different unitary conductances. Apparently there is significant channel-to-channel variation at a site in the outer pore or in the selectivity filter, leading to variability in the rate at which K(+) or Cs(+) enters the channel. Twit Text FOAVip Unitary conductance variation in Kir2 1 and in cardiac inward rectifier potassium channels ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=11566776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11566776 #FOAvip English Wikipedia <ref>{{Cite pmid|11566776}}</ref> Unitary conductance variation in Kir2 1 and in cardiac inward rectifier potassium channels #MMPMID11566776 Picones A; Keung E; Timpe LC Biophys J 2001[Oct]; 81 (4): 2035-49 PMID11566776show ga Kir2.1 (IRK1) is the complementary DNA for a component of a cardiac inwardly rectifying potassium channel. When Kir2.1 is expressed in Xenopus oocytes or human embryonic kidney (HEK) cells (150 mM external KCl), the unitary conductances form a broad distribution, ranging from 2 to 33 pS. Channels with a similarly broad distribution of unitary conductance amplitudes are also observed in recordings from adult mouse cardiac myocytes under similar experimental conditions. In all three cell types channels with conductances smaller, and occasionally larger, than the ~30 pS ones are found in the same patches as the ~30 pS openings, or in patches by themselves. The unitary conductances in patches with a single active channel are stable for the durations of the recordings. Channels of all amplitudes share several biophysical characteristics, including inward rectification, voltage sensitivity of open probability, sensitivity of open probability to external divalent cations, shape of the open channel i-V relation, and Cs(+) block. The only biophysical difference found between large and small conductance channels is that the rate constant for Cs(+) block is reduced for the small-amplitude channels. The unblocking rate constant is similar for channels of different unitary conductances. Apparently there is significant channel-to-channel variation at a site in the outer pore or in the selectivity filter, leading to variability in the rate at which K(+) or Cs(+) enters the channel. |*Potassium Channel Blockers[MESH] |*Potassium Channels, Inwardly Rectifying[MESH] |Animals[MESH] |Calcium/*metabolism/pharmacology[MESH] |Cells, Cultured/metabolism[MESH] |Cesium/pharmacology/physiology[MESH] |Cloning, Molecular[MESH] |DNA, Complementary/metabolism[MESH] |Electric Conductivity[MESH] |Humans[MESH] |Magnesium/*metabolism/pharmacology[MESH] |Male[MESH] |Membrane Potentials/physiology[MESH] |Mice[MESH] |Models, Cardiovascular[MESH] |Myocardium/cytology/*metabolism[MESH] |Oocytes/metabolism[MESH] |Patch-Clamp Techniques[MESH] |Potassium Channels/*physiology[MESH] |Xenopus[MESH]Unitary conductance variation in Kir2 1 and in cardiac inward rectifie(epmc).pdf DeepDyve Pubget Overpricing