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10.1006/bbrc.2001.5644 http://scihub22266oqcxt.onion/10.1006/bbrc.2001.5644 11563847!ä!11563847 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2001 ; 287 (3): 671-4 Nephropedia Template TP {{tp|p=11563847|t=2001. Polyvalent cation-sensing mechanism increased Na(+)-independent Mg(2+) transport in renal epithelial cells |pdf=|usr=}}{{11563847}} gab.com Text Polyvalent cation-sensing mechanism increased Na(+)-independent Mg(2+) transport in renal epithelial cells JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=11563847 #FOAvip Extracellular Ca(2+)/polyvalent cation-sensing receptor (CaSR) is capable of monitoring changes in extracellular polyvalent cation concentrations. In the present study, we investigated whether CaSR agonists reinforce the decrease of intracellular free Mg(2+) concentration ([Mg(2+)](i)) induced by extracellular Mg(2+) plus Na(+) removal. Interestingly, exposure of NRK-52E renal epithelial cells to increasing extracellular Mg(2+) concentrations from 0.8 to 15 mM for 1-2 days resulted in a twofold increase in the levels of CaSR mRNA and protein. By fluorophotometer (with mag-fura 2 fluorescent dye) and atomic absorption spectrophotometer, we confirmed that activation of CaSR by neomycin (0.5 mM) or gadolinium (1 mM) reinforced the decrease of [Mg(2+)](i) induced by Mg(2+) removal in the cells cultured in 10 mM Mg(2+)-containing medium. The neomycin-induced [Mg(2+)](i) decrease was inhibited by nicardipine (50 microM), but not by verapamil (50 microM) or amiloride (0.1 mM). These results indicate that CaSR monitors extracellular Mg(2+) concentration, and probably cause activation of Na(+)-independent Mg(2+)-transport system. Twit Text FOAVip Polyvalent cation-sensing mechanism increased Na(+)-independent Mg(2+) transport in renal epithelial cells ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=11563847 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11563847 #FOAvip English Wikipedia <ref>{{Cite pmid|11563847}}</ref> Polyvalent cation-sensing mechanism increased Na(+)-independent Mg(2+) transport in renal epithelial cells #MMPMID11563847 Ikari A; Nakajima K; Kawano K; Suketa Y Biochem Biophys Res Commun 2001[Sep]; 287 (3): 671-4 PMID11563847show ga Extracellular Ca(2+)/polyvalent cation-sensing receptor (CaSR) is capable of monitoring changes in extracellular polyvalent cation concentrations. In the present study, we investigated whether CaSR agonists reinforce the decrease of intracellular free Mg(2+) concentration ([Mg(2+)](i)) induced by extracellular Mg(2+) plus Na(+) removal. Interestingly, exposure of NRK-52E renal epithelial cells to increasing extracellular Mg(2+) concentrations from 0.8 to 15 mM for 1-2 days resulted in a twofold increase in the levels of CaSR mRNA and protein. By fluorophotometer (with mag-fura 2 fluorescent dye) and atomic absorption spectrophotometer, we confirmed that activation of CaSR by neomycin (0.5 mM) or gadolinium (1 mM) reinforced the decrease of [Mg(2+)](i) induced by Mg(2+) removal in the cells cultured in 10 mM Mg(2+)-containing medium. The neomycin-induced [Mg(2+)](i) decrease was inhibited by nicardipine (50 microM), but not by verapamil (50 microM) or amiloride (0.1 mM). These results indicate that CaSR monitors extracellular Mg(2+) concentration, and probably cause activation of Na(+)-independent Mg(2+)-transport system. |*Cations[MESH] |Amiloride/pharmacology[MESH] |Animals[MESH] |Biological Transport[MESH] |Calcium Channel Blockers/pharmacology[MESH] |Calcium/metabolism[MESH] |Cell Line[MESH] |Diuretics/pharmacology[MESH] |Dose-Response Relationship, Drug[MESH] |Electrophoresis, Polyacrylamide Gel[MESH] |Epithelial Cells/*metabolism[MESH] |Gadolinium/pharmacology[MESH] |Kidney/*cytology/*metabolism[MESH] |Magnesium/*metabolism/pharmacology[MESH] |Neomycin/pharmacology[MESH] |Nicardipine/pharmacology[MESH] |Protein Synthesis Inhibitors/pharmacology[MESH] |RNA, Messenger/metabolism[MESH] |Rats[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |Sodium/*metabolism[MESH] |Spectrometry, Fluorescence[MESH] |Spectrophotometry, Atomic[MESH] |Time Factors[MESH]Polyvalent cation-sensing mechanism increased Na(+)-independent Mg(2+)(epmc).pdf DeepDyve Pubget Overpricing