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10.1128/JVI.75.16.7555-7563.2001 http://scihub22266oqcxt.onion/10.1128/JVI.75.16.7555-7563.2001 11462027!114990!11462027     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Virol 2001 ; 75 (16): 7555-63 Nephropedia Template TP {{tp|p=11462027|t=2001. Human parvovirus B19 induces cell cycle arrest at G(2) phase with accumulation of mitotic cyclins |pdf=|usr=}}{{11462027}} gab.com Text Human parvovirus B19 induces cell cycle arrest at G(2) phase with accumulation of mitotic cyclins JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=11462027 #FOAvip Human parvovirus B19 infects specifically erythroid progenitor cells, which causes transient aplastic crises and hemolytic anemias. Here, we demonstrate that erythroblastoid UT7/Epo cells infected with B19 virus fall into growth arrest with 4N DNA, indicating G(2)/M arrest. These B19 virus-infected cells displayed accumulation of cyclin A, cyclin B1, and phosphorylated cdc2 and were accompanied by an up-regulation in the kinase activity of the cdc2-cyclin B1 complex, similar to that in cells treated with the mitotic inhibitor. However, degradation of nuclear lamina and phosphorylation of histone H3 and H1 were not seen in B19 virus-infected cells, indicating that the infected cells do not enter the M phase. Accumulation of cyclin B1 was persistently localized in the cytoplasm, but not in the nucleus, suggesting that B19 virus infection of erythroid cells raises suppression of nuclear import of cyclin B1, resulting in cell cycle arrest at the G(2) phase. The B19 virus-induced G(2)/M arrest may be the critical event in the damage of erythroid progenitor cells seen in patients with B19 virus infection. Twit Text FOAVip Human parvovirus B19 induces cell cycle arrest at G(2) phase with accumulation of mitotic cyclins ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=11462027 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11462027 #FOAvip English Wikipedia <ref>{{Cite pmid|11462027}}</ref> Human parvovirus B19 induces cell cycle arrest at G(2) phase with accumulation of mitotic cyclins #MMPMID11462027 Morita E; Tada K; Chisaka H; Asao H; Sato H; Yaegashi N; Sugamura K J Virol 2001[Aug]; 75 (16): 7555-63 PMID11462027show ga Human parvovirus B19 infects specifically erythroid progenitor cells, which causes transient aplastic crises and hemolytic anemias. Here, we demonstrate that erythroblastoid UT7/Epo cells infected with B19 virus fall into growth arrest with 4N DNA, indicating G(2)/M arrest. These B19 virus-infected cells displayed accumulation of cyclin A, cyclin B1, and phosphorylated cdc2 and were accompanied by an up-regulation in the kinase activity of the cdc2-cyclin B1 complex, similar to that in cells treated with the mitotic inhibitor. However, degradation of nuclear lamina and phosphorylation of histone H3 and H1 were not seen in B19 virus-infected cells, indicating that the infected cells do not enter the M phase. Accumulation of cyclin B1 was persistently localized in the cytoplasm, but not in the nucleus, suggesting that B19 virus infection of erythroid cells raises suppression of nuclear import of cyclin B1, resulting in cell cycle arrest at the G(2) phase. The B19 virus-induced G(2)/M arrest may be the critical event in the damage of erythroid progenitor cells seen in patients with B19 virus infection. |CDC2 Protein Kinase/physiology[MESH] |Cell Cycle[MESH] |Cell Line[MESH] |Cyclins/*physiology[MESH] |Humans[MESH] |Parvoviridae Infections/*metabolism/pathology[MESH] |Parvovirus B19, Human/*physiology[MESH] |Signal Transduction[MESH]Human parvovirus B19 induces cell cycle arrest at G(2) phase with accu(epmc).pdf DeepDyve Pubget Overpricing