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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Adv+Virus+Res 2001 ; 56 (ä): 557-82 Nephropedia Template TP
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Bornavirus tropism and targeted pathogenesis: virus-host interactions in a neurodevelopmental model #MMPMID11450312
Hornig M; Briese T; Lipkin WI
Adv Virus Res 2001[]; 56 (ä): 557-82 PMID11450312show ga
Animal models provide unique opportunities to explore interactions between host and environment. Two models have been established based on Bornavirus infection that provide new insights into mechanisms by which neurotropic agents and/or immune factors may impact developing or mature CNS circuitry to effect complex disturbances in movement and behavior. Distinct losses in DA pathways in the adult infection model, and the associated dramatic movement disorder that accompanies it, make it an intriguing model for tardive dyskinesia and dystonic syndromes. The neuropathologic, physiologic, and neurobehavioral features of BDV infection of neonates indicate that it not only provides a useful model for exploring the mechanisms by which viral and immune factors may damage developing neurocircuitry, but also has significant links to the range of biologic, neurostructural, locomotor, cognitive, and social deficits observed in serious neuropsychiatric illnesses such as autism.
|*Disease Models, Animal[MESH]
|Animals[MESH]
|Animals, Newborn[MESH]
|Borna Disease/*physiopathology/*virology[MESH]
|Borna disease virus/*physiology[MESH]
|Central Nervous System Diseases/*physiopathology/*virology[MESH]