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10.1292/jvms.63.467

http://scihub22266oqcxt.onion/10.1292/jvms.63.467
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11346186!ä!11346186

suck abstract from ncbi


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pmid11346186      J+Vet+Med+Sci 2001 ; 63 (4): 467-9
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  • Enhanced production of IL-1beta and IL-6 following endotoxin challenge in rats with dietary magnesium deficiency #MMPMID11346186
  • Nakagawa M; Oono H; Nishio A
  • J Vet Med Sci 2001[Apr]; 63 (4): 467-9 PMID11346186show ga
  • Serum IL-1beta, IL-6 and TNFalpha were not detected in control and Mg-deficient rats. These three cytokine levels in serum were increased after endotoxin challenge (1 mg/kg., i.p.), and the increase of IL-1beta and IL-6, but not TNFalpha, was significantly larger in Mg-deficient rats than in controls. Levels of mRNA for IL-1beta, IL-6 and TNFalpha in alveolar macrophages showed a tendency to decrease during Mg deficiency, but the levels of IL-1beta and TNFalpha mRNAs after endotoxin challenge were higher in Mg-deficient rats than in controls. These results suggest that the increased synthesis of cytokines by alveolar macrophages might contribute, in part, to high sensitivity to endotoxin during Mg deficiency.
  • |Animals[MESH]
  • |Interleukin-1/*biosynthesis/blood/genetics[MESH]
  • |Interleukin-6/*biosynthesis/blood/genetics[MESH]
  • |Lipopolysaccharides/*pharmacology[MESH]
  • |Macrophages, Alveolar/drug effects/*metabolism[MESH]
  • |Magnesium Deficiency/*blood/pathology[MESH]
  • |Magnesium/blood[MESH]
  • |Male[MESH]
  • |RNA, Messenger/biosynthesis/genetics[MESH]
  • |Random Allocation[MESH]
  • |Rats[MESH]
  • |Rats, Wistar[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]


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