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Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Blood 2001 ; 97 (10): 3210-7 Nephropedia Template TP
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Identification of a leukemic counterpart of the plasmacytoid dendritic cells #MMPMID11342451
Chaperot L; Bendriss N; Manches O; Gressin R; Maynadie M; Trimoreau F; Orfeuvre H; Corront B; Feuillard J; Sotto JJ; Bensa JC; Briere F; Plumas J; Jacob MC
Blood 2001[May]; 97 (10): 3210-7 PMID11342451show ga
This work aims to demonstrate that CD4(+)CD56(+) malignancies arise from transformed cells of the lymphoid-related plasmacytoid dendritic cell (pDC) subset. The analysis of malignant cells from 7 patients shows that in all cases, like pDCs, leukemic cells are negative for lineage markers CD3, CD19, CD13, CD33, and CD11c but express high levels of interleukin-3 receptor alpha chain (IL-3Ralpha), HLA-DR, and CD45RA. Tumor cells produce interferon-alpha in response to influenza virus, while upon maturation with IL-3 they become a powerful inducer of naive CD4(+) T-cell proliferation and promote their T-helper 2 polarization. As pDCs, leukemic cells also express pre-Talpha and lambda-like 14.1 transcripts, arguing in favor of a lymphoid origin. In addition, malignant cells express significant levels of CD56 and granzyme B. Overall, those observations suggest that CD4(+)CD56(+) leukemic cells could represent the malignant counterpart of pDCs, both of which are closely related to B, T, and NK cells.
Blood 2001 ; 97 (10): 3210-7
