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10.1126/science.1059817 http://scihub22266oqcxt.onion/10.1126/science.1059817 11292862!?!11292862 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=11292862&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Science 2001 ; 292 (5516): 464-8 Nephropedia Template TP {{tp|p=11292862|t=2001. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing |pdf=|usr=}}{{11292862}} gab.com Text HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=11292862 #FOAvip HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for destruction by an E3 ubiquitin ligase containing the von Hippel-Lindau tumor suppressor protein (pVHL). We found that human pVHL binds to a short HIF-derived peptide when a conserved proline residue at the core of this peptide is hydroxylated. Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing. Twit Text FOAVip HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing ????Science http://www.kidney.de/pget.php?&tw=1&pmid=11292862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11292862 #FOAvip English Wikipedia <ref>{{Cite pmid|11292862}}</ref> HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing #MMPMID11292862 Ivan M; Kondo K; Yang H; Kim W; Valiando J; Ohh M; Salic A; Asara JM; Lane WS; Kaelin WG Jr Science 2001[Apr]; 292 (5516): 464-8 PMID11292862show ga HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for destruction by an E3 ubiquitin ligase containing the von Hippel-Lindau tumor suppressor protein (pVHL). We found that human pVHL binds to a short HIF-derived peptide when a conserved proline residue at the core of this peptide is hydroxylated. Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing. |*Ligases[MESH] |*Tumor Suppressor Proteins[MESH] |*Ubiquitin-Protein Ligases[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |Basic Helix-Loop-Helix Transcription Factors[MESH] |Cell Hypoxia[MESH] |Cell Line[MESH] |Cobalt/pharmacology[MESH] |Deferoxamine/pharmacology[MESH] |Humans[MESH] |Hydroxylation[MESH] |Hydroxyproline/*metabolism[MESH] |Mass Spectrometry[MESH] |Mice[MESH] |Molecular Sequence Data[MESH] |Oxygen/*physiology[MESH] |Protein Structure, Tertiary[MESH] |Proteins/*metabolism[MESH] |Recombinant Fusion Proteins/metabolism[MESH] |Trans-Activators/chemistry/genetics/*metabolism[MESH] |Transcription Factors/*metabolism[MESH] |Tumor Cells, Cultured[MESH] |Ubiquitins/metabolism[MESH]HIFalpha targeted for VHL-mediated destruction by proline hydroxylatio(epmc).pdf DeepDyve Pubget Overpricing