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10.1016/s1386-6532(00)00179-7 http://scihub22266oqcxt.onion/10.1016/s1386-6532(00)00179-7 11166667!ä!11166667 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Virol 2001 ; 20 (3): 173-8 Nephropedia Template TP {{tp|p=11166667|t=2001. Chronic autoimmune thrombopenia/neutropenia in a boy with persistent parvovirus B19 infection |pdf=|usr=}}{{11166667}} gab.com Text Chronic autoimmune thrombopenia/neutropenia in a boy with persistent parvovirus B19 infection JO: J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=11166667 #FOAvip OBJECTIVE: We report an 11-year-old boy presenting with splenomegaly, chronic thrombocytopenia and concordant neutropenia. RESULTS: In contrast to autoantibodies against platelets, there were no detectable neutrophil-specific autoantibodies present in this patient. Extensive serologic investigations revealed increased IgM- and IgG-antibody titers against parvovirus B19. A nested polymerase chain reaction (PCR) showed parvovirus B19-specific sequences in the patient's bone-marrow cells but not in the serum. Specific antibodies against the structural proteins VP1 and VP2 in addition to those against non-structural protein NS1 of parvovirus B19 were detected by Western blot analysis. Thrombocytopenia and neutropenia responded to immunosuppressive therapy and subsequent splenectomy, the latter being necessary due to severe side-effects of steroid medication. CONCLUSION: Autoimmune thrombocytopenia/neutropenia may have been triggered and/or sustained by a chronic parvovirus B19 infection. Patients with this very rare disorder should be screened for this virus. Twit Text FOAVip Chronic autoimmune thrombopenia/neutropenia in a boy with persistent parvovirus B19 infection ????J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=11166667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11166667 #FOAvip English Wikipedia <ref>{{Cite pmid|11166667}}</ref> Chronic autoimmune thrombopenia/neutropenia in a boy with persistent parvovirus B19 infection #MMPMID11166667 Scheurlen W; Ramasubbu K; Wachowski O; Hemauer A; Modrow S J Clin Virol 2001[Feb]; 20 (3): 173-8 PMID11166667show ga OBJECTIVE: We report an 11-year-old boy presenting with splenomegaly, chronic thrombocytopenia and concordant neutropenia. RESULTS: In contrast to autoantibodies against platelets, there were no detectable neutrophil-specific autoantibodies present in this patient. Extensive serologic investigations revealed increased IgM- and IgG-antibody titers against parvovirus B19. A nested polymerase chain reaction (PCR) showed parvovirus B19-specific sequences in the patient's bone-marrow cells but not in the serum. Specific antibodies against the structural proteins VP1 and VP2 in addition to those against non-structural protein NS1 of parvovirus B19 were detected by Western blot analysis. Thrombocytopenia and neutropenia responded to immunosuppressive therapy and subsequent splenectomy, the latter being necessary due to severe side-effects of steroid medication. CONCLUSION: Autoimmune thrombocytopenia/neutropenia may have been triggered and/or sustained by a chronic parvovirus B19 infection. Patients with this very rare disorder should be screened for this virus. |Antibodies, Viral/blood[MESH] |Autoimmune Diseases/therapy/*virology[MESH] |Blotting, Western[MESH] |Child[MESH] |Chronic Disease[MESH] |Humans[MESH] |Immunosuppressive Agents/pharmacology/therapeutic use[MESH] |Male[MESH] |Neutropenia/therapy/*virology[MESH] |Parvoviridae Infections/drug therapy/*virology[MESH] |Parvovirus B19, Human/drug effects/*pathogenicity[MESH] |Polymerase Chain Reaction[MESH] |Serologic Tests[MESH]Chronic autoimmune thrombopenia/neutropenia in a boy with persistent p(epmc).pdf DeepDyve Pubget Overpricing