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10.1126/science.1058519 http://scihub22266oqcxt.onion/10.1126/science.1058519 11161216!ä!11161216 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2001 ; 291 (5506): 1043-7 Nephropedia Template TP {{tp|p=11161216|t=2001. TRP-PLIK, a bifunctional protein with kinase and ion channel activities |pdf=|usr=}}{{11161216}} gab.com Text TRP-PLIK, a bifunctional protein with kinase and ion channel activities JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=11161216 #FOAvip We cloned and characterized a protein kinase and ion channel, TRP-PLIK. As part of the long transient receptor potential channel subfamily implicated in control of cell division, it is a protein that is both an ion channel and a protein kinase. TRP-PLIK phosphorylated itself, displayed a wide tissue distribution, and, when expressed in CHO-K1 cells, constituted a nonselective, calcium-permeant, 105-picosiemen, steeply outwardly rectifying conductance. The zinc finger containing alpha-kinase domain was functional. Inactivation of the kinase activity by site-directed mutagenesis and the channel's dependence on intracellular adenosine triphosphate (ATP) demonstrated that the channel's kinase activity is essential for channel function. Twit Text FOAVip TRP-PLIK, a bifunctional protein with kinase and ion channel activities ????Science http://www.kidney.de/pget.php?&tw=1&pmid=11161216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11161216 #FOAvip English Wikipedia <ref>{{Cite pmid|11161216}}</ref> TRP-PLIK, a bifunctional protein with kinase and ion channel activities #MMPMID11161216 Runnels LW; Yue L; Clapham DE Science 2001[Feb]; 291 (5506): 1043-7 PMID11161216show ga We cloned and characterized a protein kinase and ion channel, TRP-PLIK. As part of the long transient receptor potential channel subfamily implicated in control of cell division, it is a protein that is both an ion channel and a protein kinase. TRP-PLIK phosphorylated itself, displayed a wide tissue distribution, and, when expressed in CHO-K1 cells, constituted a nonselective, calcium-permeant, 105-picosiemen, steeply outwardly rectifying conductance. The zinc finger containing alpha-kinase domain was functional. Inactivation of the kinase activity by site-directed mutagenesis and the channel's dependence on intracellular adenosine triphosphate (ATP) demonstrated that the channel's kinase activity is essential for channel function. |*Membrane Proteins[MESH] |Adenosine Triphosphate/metabolism[MESH] |Amino Acid Motifs[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |CHO Cells[MESH] |Calcium/metabolism[MESH] |Catalytic Domain[MESH] |Cations/metabolism[MESH] |Cell Line[MESH] |Cricetinae[MESH] |DNA, Complementary[MESH] |Electric Conductivity[MESH] |Humans[MESH] |Ion Channels/chemistry/*genetics/*metabolism[MESH] |Mice[MESH] |Molecular Sequence Data[MESH] |Mutation[MESH] |Myelin Basic Protein/metabolism[MESH] |Patch-Clamp Techniques[MESH] |Phosphorylation[MESH] |Protein Kinases/chemistry/*genetics/*metabolism[MESH] |Protein Serine-Threonine Kinases[MESH] |Rats[MESH] |Recombinant Fusion Proteins/chemistry/metabolism[MESH] |TRPM Cation Channels[MESH] |Transfection[MESH] |Two-Hybrid System Techniques[MESH]TRP-PLIK, a bifunctional protein with kinase and ion channel activitie(epmc).pdf DeepDyve Pubget Overpricing