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10.1074/jbc.M005107200 http://scihub22266oqcxt.onion/10.1074/jbc.M005107200 11073944!ä!11073944 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2001 ; 276 (10): 7258-65 Nephropedia Template TP {{tp|p=11073944|t=2001. Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells |pdf=|usr=}}{{11073944}} gab.com Text Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=11073944 #FOAvip Persistence of Borna disease virus (BDV) in the central nervous system causes damage to specific neuronal populations. BDV is noncytopathic, and the mechanisms underlying neuronal pathology are not well understood. One hypothesis is that infection affects the response of neurons to factors that are crucial for their proliferation, differentiation, or survival. To test this hypothesis, we analyzed the response of PC12 cells persistently infected with BDV to the neurotrophin nerve growth factor (NGF). PC12 is a neural crest-derived cell line that exhibits features of neuronal differentiation in response to NGF. We report that persistence of BDV led to a progressive change of phenotype of PC12 cells and blocked neurite outgrowth in response to NGF. Infection down-regulated the expression of synaptophysin and growth-associated protein-43, two molecules involved in neuronal plasticity, as well as the expression of the chromaffin-specific gene tyrosine hydroxylase. We showed that the block in response to NGF was due in part to the down-regulation of NGF receptors. Moreover, although BDV caused constitutive activation of the ERK1/2 pathway, activated ERKs were not translocated to the nucleus efficiently. These observations may account for the absence of neuronal differentiation of persistently infected PC12 cells treated with NGF. Twit Text FOAVip Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=11073944 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11073944 #FOAvip English Wikipedia <ref>{{Cite pmid|11073944}}</ref> Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells #MMPMID11073944 Hans A; Syan S; Crosio C; Sassone-Corsi P; Brahic M; Gonzalez-Dunia D J Biol Chem 2001[Mar]; 276 (10): 7258-65 PMID11073944show ga Persistence of Borna disease virus (BDV) in the central nervous system causes damage to specific neuronal populations. BDV is noncytopathic, and the mechanisms underlying neuronal pathology are not well understood. One hypothesis is that infection affects the response of neurons to factors that are crucial for their proliferation, differentiation, or survival. To test this hypothesis, we analyzed the response of PC12 cells persistently infected with BDV to the neurotrophin nerve growth factor (NGF). PC12 is a neural crest-derived cell line that exhibits features of neuronal differentiation in response to NGF. We report that persistence of BDV led to a progressive change of phenotype of PC12 cells and blocked neurite outgrowth in response to NGF. Infection down-regulated the expression of synaptophysin and growth-associated protein-43, two molecules involved in neuronal plasticity, as well as the expression of the chromaffin-specific gene tyrosine hydroxylase. We showed that the block in response to NGF was due in part to the down-regulation of NGF receptors. Moreover, although BDV caused constitutive activation of the ERK1/2 pathway, activated ERKs were not translocated to the nucleus efficiently. These observations may account for the absence of neuronal differentiation of persistently infected PC12 cells treated with NGF. |*MAP Kinase Signaling System[MESH] |Animals[MESH] |Blotting, Northern[MESH] |Blotting, Western[MESH] |Borna Disease/*metabolism[MESH] |Borna disease virus/*metabolism[MESH] |Cell Differentiation[MESH] |Cell Division[MESH] |Cell Nucleus/metabolism[MESH] |Down-Regulation[MESH] |Enzyme Activation[MESH] |GAP-43 Protein/biosynthesis[MESH] |Kinetics[MESH] |Microscopy, Confocal[MESH] |Microscopy, Fluorescence[MESH] |Mitogen-Activated Protein Kinase 1/metabolism[MESH] |Mitogen-Activated Protein Kinase 3[MESH] |Mitogen-Activated Protein Kinases/metabolism[MESH] |Models, Biological[MESH] |Nerve Growth Factors/pharmacology[MESH] |PC12 Cells[MESH] |Protein Transport[MESH] |RNA, Messenger/metabolism[MESH] |Rats[MESH] |Signal Transduction[MESH] |Synaptophysin/biosynthesis/metabolism[MESH] |Time Factors[MESH] |Transcription, Genetic[MESH]Borna disease virus persistent infection activates mitogen-activated p(epmc).pdf DeepDyve Pubget Overpricing